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FLASH GENE

Symbol

PRSS8

contributors: mct/npt - updated : 01-09-2016

HGNC name	protease, serine, 8
HGNC id	9491

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in hormone-refractory prostate cancers tumoral     --low   in bladder transitional cell carcinomas is associated with epithelial-mesenchymal transition (EMT), and may have functional implications in tumor invasion and resistance to chemotherapy

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Prss8(-/-) mice lack barrier formation and display fatal postnatal dehydration
	liver-specific PRSS8 knockout (LKO) mice develop insulin resistance associated with the increase in hepatic Tlr4
	Prss8-deficient newborns presented abnormal epidermis, and died soon after birth due to impaired skin function
	hypomorphic mutations in Prss8, restored placentation and normal development of Spint1-deficient embryos and prevented early embryonic lethality, mid-gestation lethality due to placental labyrinth failure, and neural tube defects in Spint2-deficient embryos