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FLASH GENE

Symbol

PPARGC1B

contributors: mct - updated : 21-07-2012

HGNC name	peroxisome proliferative activated receptor, gamma, coactivator 1, beta
HGNC id	30022

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional   deletion     induces cardiac arrhythmia

Susceptibility

to obesity

Variant & Polymorphism SNP	Ala203 allele being a risk factor for obesity

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative   therapeutic agents activating PPARGC1A, PPARGC1B would be valuable for treating neurodegenerative diseases in which mitochondrial dysfunction and oxidative damage play an important pathogenic role

ANIMAL & CELL MODELS

Pgc-1beta deficient mice exhibited greater degrees of oxidative stress, decreased cardiac efficiency, lower rates of glucose metabolism, and repression of hexokinase II protein, when subjected to transverse aortic constriction