basic FUNCTION
| protein tyrosine phosphatase, receptor type, may regulate the disassembly of focal adhesions |
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may act as an invasion inhibitor in head and neck squamous cell carcinoma |
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plays a crucial role in synapse assembly and function (Zurner 2009) |
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. play three important roles: first, in the assembly, organization, and function of presynaptic active zones; second, in the development and maintenance of dendritic spines and excitatory synapses; and third, in vesicular trafficking (Zurner 2009) |
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PHLDB1 and PHLDB2 are required, together with PPFIA1, for effective migration and tumor cell invasion, and do so by stabilizing the protrusive activity at the cell front |
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regulates the migration and invasion of human breast cancer cells |
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affects cell migration and invasion by regulating the organization of lamellipodia and invadopodia, two structures relevant to cell invasion |
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is likely involved in the organization of the postsynaptic machinery |
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PPFIA1 and ALG3 may play roles in oncogene expression in in head and neck squamous cell carcinoma (HNSCC) |
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RORB1, PPFIA1 and KCNAB2 are differentially spliced in the foveal, parafoveal and macular regions |
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plays an important role as a regulator of cell motility and tumor cell invasion and is frequently amplified in breast cancer |
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is an important contributor to oncogenic RAS/MAPK signaling |