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FLASH GENE

Symbol

SRP68

contributors: mct - updated : 09-05-2012

HGNC name	signal recognition particle 68kDa
HGNC id	11302

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	33.42 kb     17 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

in the Smith-Magenis critical reigon

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014230 17 - 2515 NP_055045 68 627 - 2006 16672232 NM_001260502 - - 2736 NP_001247431 - 589 - 2006 16672232 NM_001260503 - - 2045 NP_001247432 - 288 - 2006 16672232

EXPRESSION

Type	ubiquitous

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	RNA binding domain located near the N-terminus
	large SRP domain directly and/or indirectly engaged in the binding of SRP68
	ninety-four AA near the C terminus mediated the binding to SRP72

conjugated

RiboP

mono polymer

heteromer , monomer , dimer

HOMOLOGY

interspecies

homolog to Drosophila Cg5064

intraspecies

homolog to sequences found in the SMS repeat gene clusters SMS-REPD,SMS-REPM,REPP (see symbols)

Homologene

FAMILY

SRP family of GTP binding proteins

CATEGORY

RNA associated , receptor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
	intracellular,cytoplasm,cytosolic,ribosome
	intracellular,nucleus,nucleolus

basic FUNCTION

interacting directly with the docking protein in the endoplasmic reticulum membrane and participating possibly in the elongation arrest function

CELLULAR PROCESS

cell organization/biogenesis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex(SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
	SRP68 and SRP72, form a stable SRP68/72 heterodimer of unknown structure which is required for SRP function

INTERACTION

DNA

RNA	required for the binding of SRP72 to 7S RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS