| Symbol
| TRIM32
| contributors: mct/npt/pgu - updated : 27-11-2018
|
| HGNC name
| tripartite motif-containing 32
|
| HGNC id
| 16380
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| tumoral
|
|
| --over
|
|
were detected in gastric cancer tissues  | |
|
|
| --low
|
| |
in atopic dermatitis skin compared with healthy control and psoriatic skin suggest a defective TRIM32 pathway in atopic dermatitis pathogenesis | |
Variant & Polymorphism
| 
| |
Candidate gene
| Marker
| TRIM32 expression levels may be of potential prognostic value in gastric cancer | Therapy target
|
|
| System | Type | Disorder | Pubmed |
|---|
| cancer | hemopathy | | |
| potential therapeutic target for developmental disorders and RA-dependent leukemias | | neuromuscular | myopathy | | |
| is a possible therapeutic target to favor skeletal muscle regeneration in DMD patients |
| | |
|
| histological analysis of T32KO (Trim32 knock-out model) skeletal muscles revealed mild myopathic changes, electron microscopy showed areas with Z-line streaming and a dilated sarcotubular system with vacuoles -- the latter being a prominent feature of sarcotubular myopathy | |
Trim32-null mice showed a decrease in the concentration of neurofilament proteins in the brain and a reduced motoraxon diamete |
|
Trim32-/- mice produced higher levels of serum inflammatory cytokines and were more sensitive to loss of body weight and inflammatory death upon Salmonella typhimurium infection |