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FLASH GENE

Symbol

TRIM32

contributors: mct/npt/pgu - updated : 27-11-2018

HGNC name	tripartite motif-containing 32
HGNC id	16380

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

LGMD2H , BBS11

related resource

Limb-Girdle Muscular Dystrophy pages

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   were detected in gastric cancer tissues       --low   in atopic dermatitis skin compared with healthy control and psoriatic skin suggest a defective TRIM32 pathway in atopic dermatitis pathogenesis

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	TRIM32 expression levels may be of potential prognostic value in gastric cancer
Therapy target
	System Type Disorder Pubmed cancer hemopathy   potential therapeutic target for developmental disorders and RA-dependent leukemias neuromuscular myopathy   is a possible therapeutic target to favor skeletal muscle regeneration in DMD patients

ANIMAL & CELL MODELS

	histological analysis of T32KO (Trim32 knock-out model) skeletal muscles revealed mild myopathic changes, electron microscopy showed areas with Z-line streaming and a dilated sarcotubular system with vacuoles -- the latter being a prominent feature of sarcotubular myopathy
	Trim32-null mice showed a decrease in the concentration of neurofilament proteins in the brain and a reduced motoraxon diamete
	Trim32-/- mice produced higher levels of serum inflammatory cytokines and were more sensitive to loss of body weight and inflammatory death upon Salmonella typhimurium infection