| 1 | MYC, TRIM32, USP7
|
| A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification.
|
| Nicklas S, Hillje AL, Okawa S, Rudolph IM, Collmann FM, van Wuellen T, Del Sol A, Schwamborn JC.
|
| Cell Death Differ ell Death Differ. 2018 Jun 13. doi: 10.1038/s41418-018-0144-1. [Epub ahead of print]
2018
|
| 2 | TAX1BP1, TICAM1, TRIM32
|
| TRIM32-TAX1BP1-dependent selective autophagic degradation of TRIF negatively regulates TLR3/4-mediated innate immune responses.
|
| Yang Q, Liu TT, Lin H, Zhang M, Wei J, Luo WW, Hu YH, Zhong B, Hu MM, Shu HB.
|
| PLoS Pathog 13(9):e1006600. doi: 10.1371/journal.ppat.1006600. eCollection 2017 Sep.
2017
|
| 3 | TRIM32
|
| Overexpression of E3 ubiquitin ligase tripartite motif 32 correlates with a poor prognosis in patients with gastric cancer.
|
| Ito M, Migita K, Matsumoto S, Wakatsuki K, Tanaka T, Kunishige T, Nakade H, Nakatani M, Nakajima Y.
|
| Oncol Lett 13(5):3131-3138. doi: 10.3892/ol.2017.5806. Epub 2017 Mar 6.
2017
|
| 4 | TRIM32
|
| TRIM32 affects the recovery of motor function following spinal cord injury through regulating proliferation of glia.
|
| Fu Q, Zou MM, Zhu JW, Zhang Y, Chen WJ, Cheng M, Liu CF, Ma QH, Xu RX.
|
| Oncotarget 8(28):45380-45390. doi: 10.18632/oncotarget.17492.
2017
|
| 5 | TRIM32
|
| Trim32 Deficiency Enhances Th2 Immunity and Predisposes to Features of Atopic Dermatitis.
|
| Liu Y, Wang Z, De La Torre R, Barling A, Tsujikawa T, Hornick N, Hanifin J, Simpson E, Wang Y, Swanzey E, Wortham A, Ding H, Coussens LM, Kulesz-Martin M.
|
| J Invest Dermatol 137(2):359-366. doi: 10.1016/j.jid.2016.09.020. Epub 2016 Oct 5.
2017
|
| 6 | SNCA, TRIM32
|
| Expression of the Parkinson's Disease-Associated Gene Alpha-Synuclein is Regulated by the Neuronal Cell Fate Determinant TRIM32.
|
| Pavlou MAS, Colombo N, Fuertes-Alvarez S, Nicklas S, Cano LG, Marín MC, Goncalves J, Schwamborn JC.
|
| Mol Neurobiol 54(6):4257-4270. doi: 10.1007/s12035-016-9989-9. Epub 2016 Jun 23.
2017
|
| 7 | DDX6, TRIM32
|
| The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs.
|
| Nicklas S, Okawa S, Hillje AL, González-Cano L, Del Sol A, Schwamborn JC.
|
| Nucleic Acids Res 43(5):2638-54. doi: 10.1093/nar/gkv138. Epub 2015 Feb 26.
2015
|
| 8 | POU5F1, TRIM32
|
| TRIM32 modulates pluripotency entry and exit by directly regulating Oct4 stability.
|
| Bahnassawy L, Perumal TM, Gonzalez-Cano L, Hillje AL, Taher L, Makalowski W, Suzuki Y, Fuellen G, del Sol A, Schwamborn JC.
|
| Sci Rep 5:13456. doi: 10.1038/srep13456.
2015
|
| 9 | NDRG2, TRIM32
|
| The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.
|
| Mokhonova EI, Avliyakulov NK, Kramerova I, Kudryashova E, Haykinson MJ, Spencer MJ.
|
| Hum Mol Genet 24(10):2873-83. doi: 10.1093/hmg/ddv049. Epub 2015 Feb 20.
2015
|
| 10 | MYCN, TRIM32
|
| Trim32 facilitates degradation of MYCN on spindle poles and induces asymmetric cell division in human neuroblastoma cells.
|
| Izumi H, Kaneko Y.
|
| Cancer Res 74(19):5620-30. doi: 10.1158/0008-5472.CAN-14-0169. Epub 2014 Aug 6.
2014
|
| 11 | TP53, TRIM32
|
| E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.
|
| Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W, Feng Z.
|
| Cell Death Differ 21(11):1792-804. doi: 10.1038/cdd.2014.121. Epub 2014 Aug 22.
2014
|
| 12 | TP73, TRIM32
|
| Regulatory feedback loop between TP73 and TRIM32.
|
| Gonzalez-Cano L, Hillje AL, Fuertes-Alvarez S, Marques MM, Blanch A, Ian RW, Irwin MS, Schwamborn JC, Marín MC.
|
| Cell Death Dis 4:e704. doi: 10.1038/cddis.2013.224.
2013
|
| 13 | TRIM32
|
| TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation.
|
| Hillje AL, Pavlou MA, Beckmann E, Worlitzer MM, Bahnassawy L, Lewejohann L, Palm T, Schwamborn JC.
|
| Cell Death Dis 4:e976. doi: 10.1038/cddis.2013.487.
2013
|
| 14 | STING1, TRIM32
|
| TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination.
|
| Zhang J, Hu MM, Wang YY, Shu HB.
|
| J Biol Chem 287(34):28646-55. doi: 10.1074/jbc.M112.362608. Epub 2012 Jun 28. 2012
|
| 15 | TRIM32
|
| TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration.
|
| Nicklas S, Otto A, Wu X, Miller P, Stelzer S, Wen Y, Kuang S, Wrogemann K, Patel K, Ding H, Schwamborn JC.
|
| PLoS One 7(1):e30445. doi: 10.1371/journal.pone.0030445. Epub 2012 Jan 27.
2012
|
| 16 | TRIM32, TRIM9, UBE2G, UBE2V1, UBE2V2
|
| Functional interactions between ubiquitin E2 enzymes and TRIM proteins.
|
| Napolitano LM, Jaffray EG, Hay RT, Meroni G.
|
| Biochem J 434(2):309-19.
2011
|
| 17 | TRIM32, XIAP
|
| TRIM32 protein sensitizes cells to tumor necrosis factor (TNFα)-induced apoptosis via its RING domain-dependent E3 ligase activity against X-linked inhibitor of apoptosis (XIAP).
|
| Ryu YS, Lee Y, Lee KW, Hwang CY, Maeng JS, Kim JH, Seo YS, You KH, Song B, Kwon KS.
|
| J Biol Chem 286(29):25729-38. Epub 2011 May 31.
2011
|
| 18 | RARA, TRIM32
|
| TRIM32 promotes neural differentiation through retinoic acid receptor-mediated transcription.
|
| Sato T, Okumura F, Kano S, Kondo T, Ariga T, Hatakeyama S.
|
| J Cell Sci 124(Pt 20):3492-502. doi: 10.1242/jcs.088799. Epub 2011 Oct 7. 2011
|
| 19 | BBS11, LGMD2H, TRIM32
|
| The common missense mutation D489N in TRIM32 causing limb girdle muscular dystrophy 2H leads to loss of the mutated protein in knock-in mice resulting in a Trim32-null phenotype.
|
| Kudryashova E, Struyk A, Mokhonova E, Cannon SC, Spencer MJ.
|
| Hum Mol Genet 20(20):3925-32. doi: 10.1093/hmg/ddr311. Epub 2011 Jul 20.
2011
|
| 20 | ARL6, BBS1, BBS10, BBS11, BBS12, BBS14, BBS2, BBS3, BBS4, BBS5, BBS6, BBS7, BBS8, BBS9, CEP290, MKKS, TRIM32, TTC8
|
| Clinical and molecular characterisation of Bardet-Biedl syndrome in consanguineous populations: the power of homozygosity mapping.
|
| Abu Safieh L, Aldahmesh MA, Shamseldin H, Hashem M, Shaheen R, Alkuraya H, Al Hazzaa SA, Al-Rajhi A, Alkuraya FS.
|
| J Med Genet 47(4):236-41. Epub 2009 Oct 26.
2010
|
| 21 | BBS10, BBS11, BBS12, BBS13, BBS13, CEP290, MKS1, TRIM32
|
| Identification of 28 novel mutations in the Bardet-Biedl syndrome genes: the burden of private mutations in an extensively heterogeneous disease.
|
| Muller J, Stoetzel C, Vincent MC, Leitch CC, Laurier V, Danse JM, Hellé S, Marion V, Bennouna-Greene V, Vicaire S, Megarbane A, Kaplan J, Drouin-Garraud V, Hamdani M, Sigaudy S, Francannet C, Roume J, Bitoun P, Goldenberg A, Philip N, Odent S, Green J, Cossée M, Davis EE, Katsanis N, Bonneau D, Verloes A, Poch O, Mandel JL, Dollfus H.
|
| Hum Genet 127(5):583-93. Epub 2010 Feb 23. 2010
|
| 22 | BBS11, DBNDD1, LGMD2H, TRIM32
|
| TRIM32 is an E3 ubiquitin ligase for dysbindin.
|
| Locke M, Tinsley CL, Benson MA, Blake DJ.
|
| Hum Mol Genet 18(13):2344-58. Epub 2009 Apr 6. 2009
|
| 23 | ARL6, BBS1, BBS10, BBS12, BBS2, BBS4, BBS5, BBS7, BBS9, CEP290, MKKS, TRIM32, TTC8
|
| Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling.
|
| Seo S, Guo DF, Bugge K, Morgan DA, Rahmouni K, Sheffield VC.
|
| Hum Mol Genet 18(7):1323-31. Epub 2009 Jan 15. 2009
|
| 24 | LGMD2H, TRIM32
|
| Deficiency of the E3 ubiquitin ligase TRIM32 in mice leads to a myopathy with a neurogenic component.
|
| Kudryashova E, Wu J, Havton LA, Spencer MJ.
|
| Hum Mol Genet 18(7):1353-67. Epub 2009 Jan 19.
2009
|
| 25 | TRIM32, LGMD2H
|
| Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H.
|
| Saccone V, Palmieri M, Passamano L, Piluso G, Meroni G, Politano L, Nigro V.
|
| Hum Mutat 29(2):240-7. 2008
|
| 26 | BBS1, BBS12, TRIM32, BBS2, BBS10; ARL6, BBS4, BBS5, MKKS, BBS7, TTC8, BBS9
|
| Bardet-Biedl syndrome proteins are required for the localization of G protein-coupled receptors to primary cilia.
|
| Berbari NF, Lewis JS, Bishop GA, Askwith CC, Mykytyn K.
|
| Proc Natl Acad Sci U S A 105(11):4242-6. Epub 2008 Mar 11. 2008
|
| 27 | FMF, MEFV, MID1, MID2, PML, TRIM10, TRIM11, TRIM13, TRIM15, TRIM17, TRIM2, TRIM21, TRIM22, TRIM23, TRIM24, TRIM25, TRIM26, TRIM27, TRIM28, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM39, TRIM4, TRIM40, TRIM41, TRIM42, TRIM43, TRIM45, TRIM46, TRIM47, TRIM48, TRIM49, TRIM5, TRIM50, TRIM52, TRIM53, TRIM54, TRIM55, TRIM56, TRIM58, TRIM59, TRIM6, TRIM60, TRIM61, TRIM62, TRIM63, TRIM64, TRIM65, TRIM67, TRIM68, TRIM69, TRIM7, TRIM71, TRIM72, TRIM73, TRIM74, TRIM75, TRIM8, TRIM9, TRIML1
|
| TRIM family proteins and their emerging roles in innate immunity.
|
| Ozato K, Shin DM, Chang TH, Morse HC 3rd.
|
| Nat Rev Immunol 8(11):849-60. Review. 2008
|
| 28 | ABI2, TRIM32
|
| Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
|
| Kano S, Miyajima N, Fukuda S, Hatakeyama S.
|
| Cancer Res 68(14):5572-80.
2008
|
| 29 | TRIM32, BBS11
|
| Homozygosity mapping with SNP arrays identifies TRIM32, an E3 ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11).
|
| Chiang AP, Beck JS, Yen HJ, Tayeh MK, Scheetz TE, Swiderski RE, Nishimura DY, Braun TA, Kim KY, Huang J, Elbedour K, Carmi R, Slusarski DC, Casavant TL, Stone EM, Sheffield VC.
|
| Proc Natl Acad Sci U S A 103(16):6287-92. Epub 2006 Apr 10. 2006
|
| 30 | TRIM32
|
| Trim32 is a ubiquitin ligase mutated in limb girdle muscular dystrophy type 2H that binds to skeletal muscle myosin and ubiquitinates actin.
|
| Kudryashova E, Kudryashov D, Kramerova I, Spencer MJ.
|
| J Mol Biol 354(2):413-24. Epub 2005 Oct 10. 2005
|
| 31 | LGMD2H, TRIM32
|
| Limb-girdle muscular dystrophy type 2H associated with mutation in TRIM32, a putative E3-ubiquitin-ligase gene.
|
| Frosk P, Weiler T, Nylen E, Sudha T, Greenberg CR, Morgan K, Fujiwara TM, Wrogemann K.
|
| Am J Hum Genet 70(3):663-72. 2002
|
| 32 | ATM, TRIM10, TRIM11, TRIM14, TRIM15, TRIM16, TRIM17, TRIM2, TRIM22, TRIM26, TRIM28, TRIM29, TRIM3, TRIM31, TRIM32, TRIM33, TRIM34, TRIM35, TRIM36, TRIM37, TRIM38, TRIM4, TRIM42, TRIM5, TRIM6, TRIM7, TRIM8, TRIM9, TRIMP1
|
| The tripartite motif family identifies cell compartments.
|
| Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A.
|
| EMBO J 20(9):2140-51. 2001
|
| 33 | TRIM32
|
| Identification of a novel human zinc finger protein that specifically interacts with the activation domain of lentiviral Tat proteins.
|
| Fridell RA, Harding LS, Bogerd HP, Cullen BR.
|
| Virology 209(2):347-57.
1995
|