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FLASH GENE
Symbol PPP1R16B contributors: mct - updated : 31-01-2011
HGNC name protein phosphatase 1, regulatory (inhibitor) subunit 16B
HGNC id 15850
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • five ankyrin repeats
  • a protein phosphatase-1 (PP1)-interacting domain
  • a C-terminal CAAX box (where AA indicates aliphatic amino acid), a domain arrangement similar to that of MYPT3
  • a PP1 inhibitor
    • HOMOLOGY
    Homologene
    FAMILY
  • MYPT (myosin phosphatase target subunit) family
    • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,nucleus
    text prenylated, endothelial cell-predominant protein phosphatase 1 (PP1c) regulatory subunit that localizes to the plasma membrane of filopodia
    basic FUNCTION
  • may serve a signaling function, potentially through interaction with PPYR1
  • may be involved in endothelial cytoskeletal and barrier regulation
  • involvement in PKA-mediated moesin dephosphorylation and this dephosphorylation is important in PPP1R16B-mediated endothelial cells barrier protection
  • regulatory subunit of myosin phosphatase in endothelial cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PPYR1
  • interacts with the 37/67 kDa laminin receptor (LAMR1), targets PPYR1 to LAMR1, and LAMR1 is a PPP1R16B-dependent PPYR1 substrate
  • interacting with cystein and glycine-rich protein 1, eukaryotic translation elongation factor 2, U5 snRNP-specific protein 116 kD
  • target for PKA-primed GSK3B-mediated phosphorylation
  • binds preferentially the beta-isoform of the catalytic subunit of PP1 (PP1CB) from pulmonary artery endothelial cells
    • cell & other
    REGULATION
    Other reglulated by TGF beta 1
    phosphorylation by GSK3B activates its associated protein phosphatase 1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS