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FLASH GENE

Symbol

IRX2

contributors: mct - updated : 16-10-2024

HGNC name	iroquois homeobox 2
HGNC id	14359

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification --over   in soft tissue sarcomas tumoral     --low   significantly reduced levels of IRX2 expression in Endometrial carcinoma (EC), correlating with higher histological grades, advanced clinical stages, and diminished overall survival constitutional     --over   in the fibrotic hearts tumoral     --over   predicts poor prognosis in nasopharyngeal carcinoma tumoral fusion       IRX2-TERT fusion in clear cell sarcoma of the kidney

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	IRX2 gene may be a novel independent unfavorable prognostic factor fornasopharyngeal carcinoma (NPC) patients
	potential biomarker for Parkinson Disease
	IRX gene family could serve not only as indicators of LUAD prognosis
Therapy target
	System Type Disorder Pubmed cancer reproductive uterus targeting the IRX2-RUVBL1 axis holds promise as a potential therapeutic strategy for Endometrial carcinoma (EC) treatment cancer lung   therapeutic targets for lung adenocarcinoma (LUAD)

ANIMAL & CELL MODELS