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FLASH GENE

Symbol

IRX2

contributors: mct - updated : 16-10-2024

HGNC name	iroquois homeobox 2
HGNC id	14359

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	5.49 kb     5 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

close to IRX1 and IRX4

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_033267 4 - 3070 NP_150366 - 471 - 2015 26560478 NM_001134222 5 - 2316 NP_001127694 - 471 - 2015 26560478

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine pancreas         Respiratory lung         Urinary kidney       highly Homo sapiens Fetal Visual eye

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a homeobox DNA-binding domain
	a hexapeptide-like motif

HOMOLOGY

interspecies	ortholog to murine Irx2
	homolog to C.elegans C36F7.1

Homologene

FAMILY

TALE/IRO family of homeobox proteins

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	playing multiple roles during pattern formation of vertebrate embryos
	involved in epithelial cell differentiation as well as ductal and lobular proliferation of breast cells

CELLULAR PROCESS

nucleotide, transcription

PHYSIOLOGICAL PROCESS

development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	KDM4A catalyzed demethylation of H3K9me3 near the IRX2 promoter to activate its transcription
	KDM4A activates IRX2 transcription and the WNT/CTNNB1 signaling to induce cardiac hypertrophy and dysfunction in hypertrophic cardiomyopathy (HCM)
	IRX2 directly binds to the promoter of the early growth response factor 1 (EGR1) and subsequently initiates the transcription of several fibrosis-related genes
	IRX2 exerts negative regulation on the expression of RUVBL1, which is upregulated in Endometrial carcinoma (EC) and associated with a poorer prognosis

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   amplification --over   in soft tissue sarcomas tumoral     --low   significantly reduced levels of IRX2 expression in Endometrial carcinoma (EC), correlating with higher histological grades, advanced clinical stages, and diminished overall survival constitutional     --over   in the fibrotic hearts tumoral     --over   predicts poor prognosis in nasopharyngeal carcinoma tumoral fusion       IRX2-TERT fusion in clear cell sarcoma of the kidney

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	IRX2 gene may be a novel independent unfavorable prognostic factor fornasopharyngeal carcinoma (NPC) patients
	potential biomarker for Parkinson Disease
	IRX gene family could serve not only as indicators of LUAD prognosis
Therapy target
	System Type Disorder Pubmed cancer reproductive uterus targeting the IRX2-RUVBL1 axis holds promise as a potential therapeutic strategy for Endometrial carcinoma (EC) treatment cancer lung   therapeutic targets for lung adenocarcinoma (LUAD)

ANIMAL & CELL MODELS