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FLASH GENE
Symbol IRX2 contributors: mct - updated : 16-10-2024
HGNC name iroquois homeobox 2
HGNC id 14359
Location 5p15.33      Physical location : 2.746.280 - 2.751.769
Synonym name
  • iroquois homeobox protein 2
  • likely ortholog of mouse iroquois homeobox protein 2
  • homeodomain protein IRXA2
  • iroquois-class homeodomain protein IRX-2
    • Synonym symbol(s) IRXA2
    DNA
    TYPE functioning gene
    STRUCTURE 5.49 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    regionally located close to IRX1 and IRX4
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3070 - 471 - 2015 26560478
    5 - 2316 - 471 - 2015 26560478
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Endocrinepancreas    
    Respiratorylung    
    Urinarykidney   highly Homo sapiensFetal
    Visualeye    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a homeobox DNA-binding domain
  • a hexapeptide-like motif
    • HOMOLOGY
    interspecies ortholog to murine Irx2
    homolog to C.elegans C36F7.1
    Homologene
    FAMILY
  • TALE/IRO family of homeobox proteins
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • playing multiple roles during pattern formation of vertebrate embryos
  • involved in epithelial cell differentiation as well as ductal and lobular proliferation of breast cells
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • KDM4A catalyzed demethylation of H3K9me3 near the IRX2 promoter to activate its transcription
  • KDM4A activates IRX2 transcription and the WNT/CTNNB1 signaling to induce cardiac hypertrophy and dysfunction in hypertrophic cardiomyopathy (HCM)
  • IRX2 directly binds to the promoter of the early growth response factor 1 (EGR1) and subsequently initiates the transcription of several fibrosis-related genes
  • IRX2 exerts negative regulation on the expression of RUVBL1, which is upregulated in Endometrial carcinoma (EC) and associated with a poorer prognosis
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   amplification --over  
    in soft tissue sarcomas
    tumoral     --low  
    significantly reduced levels of IRX2 expression in Endometrial carcinoma (EC), correlating with higher histological grades, advanced clinical stages, and diminished overall survival
    constitutional     --over  
    in the fibrotic hearts
    tumoral     --over  
    predicts poor prognosis in nasopharyngeal carcinoma
    tumoral fusion      
    IRX2-TERT fusion in clear cell sarcoma of the kidney
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • IRX2 gene may be a novel independent unfavorable prognostic factor fornasopharyngeal carcinoma (NPC) patients
  • potential biomarker for Parkinson Disease
  • IRX gene family could serve not only as indicators of LUAD prognosis
    • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    targeting the IRX2-RUVBL1 axis holds promise as a potential therapeutic strategy for Endometrial carcinoma (EC) treatment
    cancerlung 
    therapeutic targets for lung adenocarcinoma (LUAD)
    ANIMAL & CELL MODELS