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FLASH GENE

Symbol

EHMT2

contributors: mct/pgu - updated : 16-06-2019

HGNC name	euchromatic histone-lysine N-methyltransferase 2
HGNC id	14129

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   significantly elevated in bladder carcinomas compared with nonneoplastic bladder tissues tumoral     --over   in aggressive lung cancer cells, and its elevated expression correlates with poor prognosis constitutional     --over   in the peripheral blood cells may support the notion of a restrictive chromatin state in autism spectrum disorders (ASD), similar to schizophrenia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     importance of EHMT2 as a promising therapeutic target for various types of cancer blood hemoglobin   novel therapeutic target for sickle cell disease (SCD)

ANIMAL & CELL MODELS