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FLASH GENE
Symbol TNXB contributors: mct - updated : 27-09-2011
HGNC name tenascin XB
HGNC id 11976
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • nineteen Egf-like motifs
  • thirty four fibronectin type III-like domains
  • a fibrinogen-like domain
    • HOMOLOGY
    interspecies homolog to murine Tnxb
    intraspecies homolog to CYP21A2
    Homologene
    FAMILY tenascin family of glycoproteins
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    text
  • extracellular matrix glycoprotein
  • TNXB and KIF11 proteins were co-localized in the cytoplasm in interphase and mitosis, but TNXB did not localize on mitotic spindle microtubules, on which KIF11 prominently localized in mitosis
    • basic FUNCTION
  • playing a role in interactions between cell and ECM, antiadhesive effect, inhibiting cell migration, and in maintaining homeostasis of the extracellular matrix
  • via trimerization and multiple interactions with components of collagenous fibrils, can play a crucial role in the organisation of extracellular matrices
  • role in supporting the growth of epithelial tumors
  • unlikely involved in matrix deposition in the early phase of wound healing, but required in the later phase when remodeling and maturation of the matrix establishes and improves its biomechanical properties
  • potentially having a role in the pathogenesis of disorders in the CNS
  • possible involvement of TNXB in the function of KIF11
  • might be directly involved in determining the mechanical properties of collagen-rich tissues
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EDSL1 , VUR8
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in malignant mesothelioma compared with ovarian/peritoneal serous carcinoma
    Susceptibility
  • to rheumatoid arthritis
  • to systemic lupus erythematosus
    • Variant & Polymorphism SNP increasing the risk of systemic lupus erythematosus
    Candidate gene
    Marker
  • may be a new diagnostic marker of malignant mesothelioma in the differential diagnosis of cancers involving the serosal cavities, particularly in the differential diagnosis between this tumor and ovarian/peritoneal serous carcinoma
    • Therapy target
    ANIMAL & CELL MODELS