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FLASH GENE

Symbol

OSBPL7

contributors: mct - updated : 09-02-2013

HGNC name	oxysterol binding protein-like 7
HGNC id	16387

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine       highly Nervous brain diencephalon epithalamus pineal gland     brain basal nuclei

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N terminal pleckstrin homology PH domain
	a highly conserved OSBP-type sterol binding domain in the C terminus

HOMOLOGY

Homologene

FAMILY

oxysterol binding protein family

CATEGORY

receptor

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic

basic FUNCTION	may be involved in protein-protein and protein-lipid interactions
	putative role in communication between the ER and the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

interaction partner of OSBPL7, GABARAPL2 which regulates Golgi SNARE of 28kDa (GS28) function and stability, and plays a role in autophagosome biogenesis

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS