| basic FUNCTION
| E3 ubiquitin-protein ligase that interacts with the Toll/interleukin-1 receptor domain of TLRs and promotes their proteolytic degradation (Fearns 2006) |
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versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection (Nakhaei 2009) |
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appear to be involved in the movement of TLR4 to the lysosome for degradation (McGettrick 2010) |
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RNF216 is a key negative regulator of sustained KIR2DL4-mediated NFKB1 signaling from internalized KIR2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes  |
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RNF216 promoted Colorectal cancer cell proliferation and migration by negatively regulating BECN1-dependent autophagy |
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is an E3 ubiquitin ligase that recognizes and facilitates the ubiquitination of its target for degradation by the ubiquitin-proteasome system (UPS) |
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essential function of RNF216 in spermatogenesis and male fertility, suggesting a critical role for RNF216 in human gonadal development |
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RNF216 regulates the migration of GNRH1 neuron by suppressing BECN1 mediated autophagy, suggesting a potential contribution of autophagy to the hypogonadotropic hypogonadism |
