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FLASH GENE
Symbol RNF216 contributors: mct/npt - updated : 06-12-2019
HGNC name ring finger protein 216
HGNC id 21698
Corresponding disease
GDHS Gordon Holmes syndrome
Location 7p22.1      Physical location : 5.659.677 - 5.821.292
Synonym name
  • ubiquitin conjugating enzyme 7 interacting protein 1
  • zinc finger protein inhibiting NF- kappa-B
  • triad domain-containing protein 3
    • Synonym symbol(s) TRIAD3, U7I1, UBCE7IP1, ZIN, CAHH
    EC.number 6.3.2.-/ 2.3.2.27
    DNA
    TYPE functioning gene
    STRUCTURE 161.61 kb     17 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    17 - 5793 - 923 - 2014 25484083
    17 - 5622 99 866 - 2014 25484083
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a double ring finger linked (DRIL) motif
    • HOMOLOGY
    Homologene
    FAMILY
  • zinc finger family
  • ubiquitin ligase of the RING-in-between-RING family
    • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • E3 ubiquitin-protein ligase that interacts with the Toll/interleukin-1 receptor domain of TLRs and promotes their proteolytic degradation (Fearns 2006)
  • versatile E3 ubiquitin ligase that negatively regulates RIG-like receptor signaling by targeting TRAF3 for degradation following RNA virus infection (Nakhaei 2009)
  • appear to be involved in the movement of TLR4 to the lysosome for degradation (McGettrick 2010)
  • RNF216 is a key negative regulator of sustained KIR2DL4-mediated NFKB1 signaling from internalized KIR2DL4, which functions by promoting ubiquitylation and degradation of endocytosed receptor from early endosomes
  • RNF216 promoted Colorectal cancer cell proliferation and migration by negatively regulating BECN1-dependent autophagy
  • is an E3 ubiquitin ligase that recognizes and facilitates the ubiquitination of its target for degradation by the ubiquitin-proteasome system (UPS)
  • essential function of RNF216 in spermatogenesis and male fertility, suggesting a critical role for RNF216 in human gonadal development
  • RNF216 regulates the migration of GNRH1 neuron by suppressing BECN1 mediated autophagy, suggesting a potential contribution of autophagy to the hypogonadotropic hypogonadism
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • E3 ubiquitin-protein ligase to RIPK1 and Hsp90 and RNF216 cooperatively maintain the homeostasis of RIPK1 (Fearns 2006)
  • RNF216 is an interaction partner for the KIR2DL4 cytoplasmic domain
  • RNF216 interacts with BECN1, a key regulator in autophagy, and leads to ubiquitination of BECN1, thereby contributing to BECN1 degradation
  • TLR8 proteasomal disposal through RNF216 in response RNA ligands regulate TLR8 cellular concentrations and may have implications innate immune signaling
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) GDHS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potential biomarker for inhibiting colorectal cancer (CRC development and progression
    • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivecolon
    therapeutic target for inhibiting CRC development and progression
    immunologyinflammatory 
    may be a target for treatment of inflammatory diseases
    ANIMAL & CELL MODELS