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FLASH GENE

Symbol

SIRT4

contributors: mct - updated : 05-05-2020

HGNC name	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
HGNC id	14932

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

mouse oocytes overexpressing Sirt4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species (ROS) level, with the severely disrupted spindle/chromosome organization