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FLASH GENE

Symbol

SIRT4

contributors: mct - updated : 05-05-2020

HGNC name	sirtuin (silent mating type information regulation 2 homolog) 4 (S. cerevisiae)
HGNC id	14932

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function           loss of SIRT4 in insulinoma cells activates GLUD1, thereby upregulating amino acid-stimulated insulin secretion tumoral     --low   in hepatocellular carcinoma tumour tissues, and the expression of SIRT4 in peritumour tissues was positively associated with survival in patients constitutional     --over   Protein levels of SIRT 4 were significantly higher in HUVECs from HELLP compared to control after 60 and 120 minutes of hypoxia

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed diabete type 2   its inhibition increases fat oxidative capacity in liver and mitochondrial function in muscle, which might provide therapeutic benefits for diseases associated with ectopic lipid storage such as type 2 diabetes cancer digestive colon may serve as a novel therapeutic target in colorectal cancer

ANIMAL & CELL MODELS

mouse oocytes overexpressing Sirt4 are unable to completely progress through meiosis, showing the inadequate mitochondrial redistribution, lowered ATP content, elevated reactive oxygen species (ROS) level, with the severely disrupted spindle/chromosome organization