| basic FUNCTION
| by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers  |
|
playing a role in the regulation of insulin secretion |
|
lacks deacetylase activities but efficiently works as an ADP-ribosyltransferase |
|
play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging |
|
required to maintain cell survival after genotoxic stress in a NAD+-dependent manner |
|
with SIRT3, modulate mitochondrial function in response to its [NADH]/[NAD+] ratio by regulating the activity of key metabolic enzymes |
|
implicated in the regulation of insulin secretion by modulation of glutamate dehydrogenase |
|
playing a role in regulating hepatic fat metabolism |
|
is potentially a negative regulator of fat oxidation and overall mitochondrial oxidative metabolism |
|
negative regulator of oxidative metabolism, which is in stark contrast to the functions of SIRT1 and SIRT3, which enhance the oxidative capacity of tissues |
|
connected to keratinocyte differentiation, chronological aging, ultraviolet radiation (UVR) response, alopecia, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) |
|
SIRT4 and GLUD1 overexpression play antagonistic roles in regulating gliogenesis |
|
SIRT4 is an important regulator of lipid homeostasis |
|
SIRT4 is a guardian of cellular metabolism |
|
is a crucial regulator of the stress resistance of cancer cells |
|
essential roles in stress resistance and may be an important therapeutic target for cancer treatment |
|
SIRT4 is a crucial player maintaining insulin secretion and glucose homeostasis during aging |
|
stress-responsive mitochondrial sirtuin SIRT4 controls cellular energy metabolism in a NAD+-dependent manner and is implicated in cellular senescence and aging |
|
modulates energy homeostasis in multiple cell types and tissues |
|
critical role for SIRT4 in the control of energy metabolism and meiotic apparatus during oocyte maturation and SIRT4 is an essential factor determining oocyte quality |
|
in mitochondrial sirtuins, SIRT4 was the last of less well-understood mitochondrial sirtuins especially for its robust enzymatic activity |
|
having robust deacylase activity in addition to the already accepted substrate-dependent lipoamidase and deacetylase properties |
|
is proposed as either a mitochondrial tumor suppressor or a tumor-promoting protein in a context-dependent manner |
