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FLASH GENE

Symbol

SIRT7

contributors: mct - updated : 24-01-2019

HGNC name	sirtuin (silent mating type information regulation 2 homolog) 7 (S. cerevisiae)
HGNC id	14935

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   overexpressed in human thyroid carcinoma cell lines and tissues

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     is a promising pharmacologic target for epigenetic cancer therapy

ANIMAL & CELL MODELS

	Sirt7 deficiency in mice induces multisystemic mitochondrial dysfunction, which is reflected by increased blood lactate levels, reduced exercise performance, cardiac dysfunction, hepatic microvesicular steatosis, and age-related hearing loss
	suppresses ER stress and reverts the fatty liver disease in diet-induced obese mice