| basic FUNCTION
| NAD(+) ADP ribosyltransferase with a protein deacetylase activity |
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acting via the formation of large multiprotein complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) |
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positive regulator of RNA polymerase I (Pol I) transcription and is required for cell viability in mammals |
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by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers (Saunders 2007) |
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involved in resumption of rDNA transcription at the exit from mitosis  |
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may enable cells to sustain critical metabolic functions by inhibiting cell growth even under severe stress conditions |
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is an NAD+-dependent H3K18Ac (acetylated lysine 18 of histone H3) deacetylase that stabilizes the transformed state of cancer cells |
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pivotal role for SIRT7 in chromatin regulation, cellular transformation programs and tumour formation |
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association between loss of nucleolar SIRT7 and replicative senescence |
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novel molecular function of SIRT7 as a negative regulator of HIF signaling |
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is involved in multiple pathways involved in ribosome biogenesis, and potentially its down-regulation may contribute to an antitumor effect, partly through the inhibition of protein synthesis |
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participates in rDNA transcription in the nucleolus |
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is at the crossroads of chromatin signaling, metabolic, and tumor-regulatory pathways |
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hepatic SIRT7 controls lipid metabolism in liver by regulating the ubiquitin-proteasome pathway |
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is a crucial regulator of mitochondrial homeostasis |
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attenuates DNA damage, SAPK activation and TP53 response thereby promoting cellular survival under conditions of genomic stress |
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SIRT7 and DDX21 cooperate to prevent R-loop accumulation, thus safeguarding genome integrity |
