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| SIRT1 is not only induced in mouse models of neurodegeneration but also in primary cultured neurons under neurotoxic stresses |
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Sir2-alpha null mice smaller at birth and died during the early postnatal period |
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Disruption of Sirt1 expression in zebrafish and mice resulted in defective blood vessel formation and blunted ischemia-induced neovascularization |
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Sirt1-deficient mice are reported to exhibit severe neural defects, including exencephaly and disturbed neuroretinal morphogenesis |
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Sirt1 knockdown in mIMCD3 cells enhanced alpha-ENaC mRNA levels and alpha-ENaC promoter activity, and inhibited global H3K79 methylation, particularly H3K79 trimethylation, in chromatin associated with the alpha-ENaC promoter  |
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mouse embryo fibroblasts lacking SIRT1 contain reduced PML protein levels ( |