| 1 | PLKHD, SIRT1, TULP3
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| Progressive liver, kidney, and heart degeneration in children and adults affected by TULP3 mutations
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| Devane J, Ott E, Olinger EG, Epting D, Decker E, Friedrich A, Bachmann N, Renschler G, Eisenberger T, Briem-Richter A, Grabhorn EF, Powell L, Wilson IJ, Rice SJ, Miles CG, Wood K; Genomics England Research Consortium, Trivedi P, Hirschfield G, Pietrobattista A, Wohler E, Mezina A, Sobreira N, Agolini E, Maggiore G, Dahmer-Heath M, Yilmaz A, Boerries M, Metzger P, Schell C, Grünewald I, Konrad M, König J, Schlevogt B, Sayer JA, Bergmann C.
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| Am J Hum Genet. May 5;109(5):928-943. doi: 10.1016/j.ajhg.2022.03.015. Epub 2022 Apr 8. 2022
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| 2 | HDAC4, HDAC5, NAE1, SIRT1
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| Neddylation Regulates Class IIa and III Histone Deacetylases to Mediate Myoblast Differentiation
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| Zhou H, Su H, Chen W.
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| Int J Mol Sci. Sep 1;22(17):9509. doi: 10.3390/ijms22179509. 2021
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| 3 | NQO1, SIRT1
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| NQO1 Binds and Supports SIRT1 Function.
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| Tsvetkov P, Adler J, Strobelt R, Adamovich Y, Asher G, Reuven N, Shaul Y.
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| Front Pharmacol. Jun 21;12:671929. doi: 10.3389/fphar.2021.671929. 2021
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| 4 | CACUL1, KDM1A, PPARG, SIRT1
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| CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.
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| Jang MJ, Park UH, Kim JW, Choi H, Um SJ, Kim EJ.
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| Cell Death Dis 8(12):3201. doi: 10.1038/s41419-017-0070-z.
2017
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| 5 | CCAR2, SIRT1, UCP1
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| Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction.
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| Nøhr MK, Bobba N, Richelsen B, Lund S, Pedersen SB.
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| Int J Mol Sci 18(5). pii: E1006. doi: 10.3390/ijms18051006.
2017
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| 6 | KL, SIRT1
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| Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
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| Gao D, Zuo Z, Tian J, Ali Q, Lin Y, Lei H, Sun Z.
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| Hypertension ypertension. 2016 Sep 12. pii: HYPERTENSIONAHA.116.07709. [Epub ahead of print]
2016
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| 7 | ENOX2, SIRT1
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| Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).
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| Lin MH, Lee YH, Cheng HL, Chen HY, Jhuang FH, Chueh PJ.
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| Molecules 21(7). pii: E849. doi: 10.3390/molecules21070849.
2016
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| 8 | SIRT1, SIRT2
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| Sirtuins 1 and 2 Are Universal Histone Deacetylases.
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| Hsu WW, Wu B, Liu WR.
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| ACS Chem Biol 11(3):792-9. doi: 10.1021/acschembio.5b00886. Epub 2016 Feb 5.
2016
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| 9 | DOT1L, SIRT1
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| DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
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| Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA.
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| Nat Med 21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30.
2015
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| 10 | SIRT1, TRIM28
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| KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.
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| Lin YH, Yuan J, Pei H, Liu T, Ann DK, Lou Z.
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| PLoS One 10(4):e0123935. doi: 10.1371/journal.pone.0123935. eCollection 2015.
2015
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| 11 | RORC, SIRT1
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| SIRT1 deacetylates RORγt and enhances Th17 cell generation.
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| Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.
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| J Exp Med 212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. Erratum in: J Exp Med. 2015 Jun 1;212(6):973.
2015
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| 12 | RELB, SIRT1
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| Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
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| Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE.
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| J Biol Chem 290(1):396-408. doi: 10.1074/jbc.M114.566349. Epub 2014 Nov 17.
2015
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| 13 | ATP6V1B2, SIRT1
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| SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes.
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| Kim SY, Zhang Q, Brunmeir R, Han W, Xu F.
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| PLoS One 10(7):e0133448. doi: 10.1371/journal.pone.0133448. eCollection 2015.
2015
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| 14 | SIRT1, SIRT2, TIAM1
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| The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration
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| Saxena M, Dykes SS, Malyarchuk S, Wang AE, Cardelli JA, Pruitt K.
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| Oncogene. Jan 8;34(2):188-98. doi: 10.1038/onc.2013.549. Epub 2013 Dec 23. 2015
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| 15 | NAMPT, SIRT1
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| The function of nicotinamide phosphoribosyltransferase in the heart.
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| Hsu CP, Yamamoto T, Oka S, Sadoshima J.
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| DNA Repair (Amst) NA Repair (Amst). 2014 Sep 29. pii: S1568-7864(14)00221-3. doi: 10.1016/j.dnarep.2014.08.005. [Epub ahead of print]
2014
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| 16 | FOXO3, SIRT1, TERT
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| FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.
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| Yamashita S, Ogawa K, Ikei T, Fujiki T, Katakura Y.
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| PLoS One 9(7):e101864. doi: 10.1371/journal.pone.0101864. eCollection 2014.
2014
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| 17 | CCAR2, CHEK2, SIRT1
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| Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.
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| Magni M, Ruscica V, Buscemi G, Kim JE, Nachimuthu BT, Fontanella E, Delia D, Zannini L.
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| Nucleic Acids Res 42(21):13150-60. doi: 10.1093/nar/gku1065. Epub 2014 Oct 31.
2014
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| 18 | PACS2, SIRT1, TP53
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| The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.
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| Atkins KM, Thomas LL, Barroso-González J, Thomas L, Auclair S, Yin J, Kang H, Chung JH, Dikeakos JD, Thomas G.
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| Cell Rep 8(5):1545-57. doi: 10.1016/j.celrep.2014.07.049. Epub 2014 Aug 21.
2014
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| 19 | CARM1, CCNA1, CCNB1, ELAVL1, FOS, SIRT1
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| Loss of CARM1 is linked to reduced HuR function in replicative senescence.
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| Pang L, Tian H, Chang N, Yi J, Xue L, Jiang B, Gorospe M, Zhang X, Wang W.
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| BMC Mol Biol 14:15. doi: 10.1186/1471-2199-14-15.
2013
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| 20 | SIRT1, STAT5A, STAT5B
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| SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
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| Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y.
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| Proc Natl Acad Sci U S A 110(37):14948-53. doi: 10.1073/pnas.1220606110. Epub 2013 Aug 26.
2013
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| 21 | CCAR2, KAT8, SIRT1
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| hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
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| Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J.
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| Mol Cell Biol 33(24):4960-70. doi: 10.1128/MCB.00874-13. Epub 2013 Oct 14.
2013
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| 22 | HIPK2, SIRT1
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| SIRT1 negatively regulates the protein stability of HIPK2.
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| Hwang J, Lee SY, Choi JR, Shin KS, Choi CY, Kang SJ.
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| Biochem Biophys Res Commun 441(4):799-804. doi: 10.1016/j.bbrc.2013.10.133. Epub 2013 Nov 5.
2013
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| 23 | RRP8, SIRT1, SUV39H1
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| Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability.
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| Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J.
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| Mol Cell Biol 33(19):3835-48. doi: 10.1128/MCB.00476-13. Epub 2013 Jul 29.
2013
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| 24 | NMNAT1, RRP8, SIRT1
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| The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription.
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| Song T, Yang L, Kabra N, Chen L, Koomen J, Haura EB, Chen J.
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| J Biol Chem 288(29):20908-17. doi: 10.1074/jbc.M113.470302. Epub 2013 Jun 4.
2013
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| 25 | NAMPT, NR1D1, SIRT1
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| Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
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| Vieira E, Marroquí L, Figueroa AL, Merino B, Fernandez-Ruiz R, Nadal A, Burris TP, Gomis R, Quesada I.
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| PLoS One 8(7):e69939. doi: 10.1371/journal.pone.0069939.
2013
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| 26 | RETN, SIRT1
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| Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
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| Yu A, Zheng Y, Zhang R, Huang J, Zhu Z, Zhou R, Jin D, Yang Z.
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| Mol Cell Endocrinol 377(1-2):23-32. doi: 10.1016/j.mce.2013.06.028. Epub 2013 Jul 1.
2013
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| 27 | SIRT1, TDG
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| Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.
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| Madabushi A, Hwang BJ, Jin J, Lu AL.
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| Biochem J 456(1):89-98. doi: 10.1042/BJ20130670.
2013
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| 28 | HNF1A, SIRT1
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| Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.
|
| Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X.
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| Mol Cell Biol 32(7):1226-36. Epub 2012 Jan 30.
2012
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| 29 | SIRT1
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| NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.
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| Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y.
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| Biochem Biophys Res Commun 418(4):811-7. doi: 10.1016/j.bbrc.2012.01.109. Epub 2012 Jan 28.
2012
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| 30 | SIRT1
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| A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes.
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| Shah ZH, Ahmed SU, Ford JR, Allison SJ, Knight JR, Milner J.
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| Mol Cell Biol 32(3):704-16. doi: 10.1128/MCB.06448-11. Epub 2011 Nov 28.
2012
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| 31 | FOXO3, GADD45A, NAMPT, SIRT1
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| NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.
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| Thakur BK, Lippka Y, Dittrich T, Chandra P, Skokowa J, Welte K.
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| Biochem Biophys Res Commun 420(4):714-20. doi: 10.1016/j.bbrc.2012.03.017. Epub 2012 Mar 10.
2012
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| 32 | SIRT1
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| Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes.
|
| Busch F, Mobasheri A, Shayan P, Stahlmann R, Shakibaei M.
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| J Biol Chem 287(31):25770-81. doi: 10.1074/jbc.M112.355420. Epub 2012 Jun 11.
2012
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| 33 | KAT5, KAT8, SIRT1
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| SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60.
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| Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E.
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| Mol Cell Biol 32(14):2823-36. doi: 10.1128/MCB.00496-12. Epub 2012 May 14.
2012
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| 34 | EPO, GATA4, SIRT1, TAL1
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| GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
|
| Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT.
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| J Biol Chem 287(36):30157-69. doi: 10.1074/jbc.M112.376640. Epub 2012 Jul 7.
2012
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| 35 | SIRT1
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| Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
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| Shan J, Pang S, Wanyan H, Xie W, Qin X, Yan B.
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| Biochem Biophys Res Commun 425(4):741-5. doi: 10.1016/j.bbrc.2012.07.145.
2012
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| 36 | SIRT1
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| Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
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| Zhang A, Wang H, Qin X, Pang S, Yan B.
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| Biochem Biophys Res Commun 422(4):693-6. doi: 10.1016/j.bbrc.2012.05.059. Epub 2012 May 18.
2012
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| 37 | CTNNB1, SIRT1, ZG16B
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| SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.
|
| Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH.
|
| Biochem Biophys Res Commun 423(2):270-5. doi: 10.1016/j.bbrc.2012.05.107. Epub 2012 May 26.
2012
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| 38 | IL12A, IL12B, SIRT1
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| Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.
|
| Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS.
|
| J Biol Chem 287(42):35689-701. doi: 10.1074/jbc.M112.391839. Epub 2012 Aug 14.
2012
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| 39 | COL1A2, NAMPT, RFX5, SIRT1
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| SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells.
|
| Xia J, Wu X, Yang Y, Zhao Y, Fang M, Xie W, Wang H, Xu Y.
|
| Biochem Biophys Res Commun 428(2):264-70. doi: 10.1016/j.bbrc.2012.10.043. Epub 2012 Oct 15.
2012
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| 40 | FOXO1, NDN, SIRT1, TP53
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| Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis.
|
| Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K.
|
| J Neurosci 32(16):5562-72. doi: 10.1523/JNEUROSCI.0142-12.2012.
2012
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| 41 | SIRT1
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| SIRT1 stabilizes PML promoting its sumoylation.
|
| Campagna M, Herranz D, Garcia MA, Marcos-Villar L, González-Santamaría J, Gallego P, Gutierrez S, Collado M, Serrano M, Esteban M, Rivas C.
|
| Cell Death Differ. 18(1):72-9. 2011
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| 42 | SIRT1
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| Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells.
|
| Zhang Y, Wang J, Chen G, Fan D, Deng M.
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| Biochem Biophys Res Commun 404(2):610-4. Epub 2010 Dec 7.
2011
|
| 43 | FOXO1, GADD45A, SIRT1
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| FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.
|
| Hughes KJ, Meares GP, Hansen PA, Corbett JA.
|
| J Biol Chem 286(10):8338-48. Epub 2011 Jan 1.
2011
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| 44 | SIRT1, SUV39H1
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| Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.
|
| Bosch-Presegué L, Raurell-Vila H, Marazuela-Duque A, Kane-Goldsmith N, Valle A, Oliver J, Serrano L, Vaquero A.
|
| Mol Cell 42(2):210-23.
2011
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| 45 | FOXL2, SIRT1
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| Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.
|
| Benayoun BA, Georges AB, L'Hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M, Veitia RA.
|
| Hum Mol Genet 20(9):1673-86. Epub 2011 Feb 2.
2011
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| 46 | NOTCH1, SIRT1
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| Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
|
| Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M.
|
| Nature 473(7346):234-8. Epub 2011 Apr 17.
2011
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| 47 | KDM1A, SIRT1
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| A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
|
| Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM.
|
| Mol Cell 42(5):689-99. Epub 2011 May 19.
2011
|
| 48 | SIRT1
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| Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
|
| Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW, Ng MH, Ho CY, Cheng SH, Lai PB, Yu J, Ng HK, Ling MT, Huang AL, Cai XF, Ko BC.
|
| Cancer Res 71(12):4138-49. Epub 2011 Apr 28.
2011
|
| 49 | PPARA, SIRT1
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| Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
|
| Planavila A, Iglesias R, Giralt M, Villarroya F.
|
| Cardiovasc Res 90(2):276-84. Epub 2010 Nov 29.
2011
|
| 50 | MAPK8, SIRT1
|
| Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
|
| Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J.
|
| J Biol Chem 286(25):22227-34. Epub 2011 May 3.
2011
|
| 51 | SIRT1
|
| Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
|
| Fatoba ST, Okorokov AL.
|
| Cell Cycle 10(14):2317-22. Epub 2011 Jul 15.
2011
|
| 52 | EP300, NPAT, SIRT1
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| CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.
|
| He H, Yu FX, Sun C, Luo Y.
|
| PLoS One 6(7):e22088. doi: 10.1371/journal.pone.0022088. Epub 2011 Jul 15.
2011
|
| 53 | SIRT1
|
| The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
|
| Gerhart-Hines Z, Dominy JE Jr, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P.
|
| Mol Cell 44(6):851-63. doi: 10.1016/j.molcel.2011.12.005.
2011
|
| 54 | DNMT1, SIRT1
|
| SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
|
| Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E.
|
| Mol Cell Biol 31(23):4720-34. doi: 10.1128/MCB.06147-11. Epub 2011 Sep 26.
2011
|
| 55 | KAT8, SIRT1
|
| Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin.
|
| Lu L, Li L, Lv X, Wu XS, Liu DP, Liang CC.
|
| Cell Res 21(8):1182-95. doi: 10.1038/cr.2011.71. Epub 2011 Apr 19.
2011
|
| 56 | SIRT1, SIRT4
|
| The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes.
|
| Song R, Xu W, Chen Y, Li Z, Zeng Y, Fu Y.
|
| Eur J Histochem 55(1):e10. doi: 10.4081/ejh.2011.e10.
2011
|
| 57 | DYRK1A, DYRK3, SIRT1
|
| DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
|
| Guo X, Williams JG, Schug TT, Li X.
|
| J Biol Chem 285(17):13223-32. Epub 2010 Feb 18.
2010
|
| 58 | APEX1, SIRT1
|
| SIRT1 deacetylates APE1 and regulates cellular base excision repair.
|
| Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K.
|
| Nucleic Acids Res 38(3):832-45. Epub 2009 Nov 24.
2010
|
| 59 | SIRT1
|
| SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
|
| Holloway KR, Calhoun TN, Saxena M, Metoyer CF, Kandler EF, Rivera CA, Pruitt K.
|
| Proc Natl Acad Sci U S A 107(20):9216-21. Epub 2010 May 3.PMID: 20439735 2010
|
| 60 | SIRT1
|
| Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
|
| Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF.
|
| Proc Natl Acad Sci U S A 107(31):13736-41. Epub 2010 Jul 14.PMID: 20631301 2010
|
| 61 | NR0B2, NR5A2, SIRT1
|
| Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation.
|
| Chanda D, Xie YB, Choi HS.
|
| Nucleic Acids Res 38(14):4607-19. Epub 2010 Apr 7.
2010
|
| 62 | SIRT1, SIRT2
|
| SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
|
| Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW.
|
| Mol Cancer Ther 9(4):844-55. Epub 2010 Apr 6.PMID: 20371709 2010
|
| 63 | SIRT1
|
| Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
|
| Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.
|
| Genes Dev. 24(13):1403-17. 2010
|
| 64 | SIRT1, SREBF1
|
| SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
|
| Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK.
|
| J Biol Chem 285(44):33959-70. Epub 2010 Sep 3.
2010
|
| 65 | SIRT1, XPC
|
| Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
|
| Ming M, Shea CR, Guo X, Li X, Soltani K, Han W, He YY.
|
| Proc Natl Acad Sci U S A 107(52):22623-8. Epub 2010 Dec 13.
2010
|
| 66 | SIRT1
|
| SIRT1 contributes to telomere maintenance and augments global homologous recombination.
|
| Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA.
|
| J Cell Biol 191(7):1299-313.
2010
|
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2009
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