Citations for
1CACUL1, KDM1A, PPARG, SIRT1
CACUL1 reciprocally regulates SIRT1 and LSD1 to repress PPARγ and inhibit adipogenesis.
Jang MJ, Park UH, Kim JW, Choi H, Um SJ, Kim EJ.
Cell Death Dis 8(12):3201. doi: 10.1038/s41419-017-0070-z. 2017
2CCAR2, SIRT1, UCP1
Inflammation Downregulates UCP1 Expression in Brown Adipocytes Potentially via SIRT1 and DBC1 Interaction.
Nøhr MK, Bobba N, Richelsen B, Lund S, Pedersen SB.
Int J Mol Sci 18(5). pii: E1006. doi: 10.3390/ijms18051006. 2017
3KL, SIRT1
Activation of SIRT1 Attenuates Klotho Deficiency-Induced Arterial Stiffness and Hypertension by Enhancing AMP-Activated Protein Kinase Activity.
Gao D, Zuo Z, Tian J, Ali Q, Lin Y, Lei H, Sun Z.
Hypertension ypertension. 2016 Sep 12. pii: HYPERTENSIONAHA.116.07709. [Epub ahead of print] 2016
4ENOX2, SIRT1
Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).
Lin MH, Lee YH, Cheng HL, Chen HY, Jhuang FH, Chueh PJ.
Molecules 21(7). pii: E849. doi: 10.3390/molecules21070849. 2016
5SIRT1, SIRT2
Sirtuins 1 and 2 Are Universal Histone Deacetylases.
Hsu WW, Wu B, Liu WR.
ACS Chem Biol 11(3):792-9. doi: 10.1021/acschembio.5b00886. Epub 2016 Feb 5. 2016
6DOT1L, SIRT1
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.
Chen CW, Koche RP, Sinha AU, Deshpande AJ, Zhu N, Eng R, Doench JG, Xu H, Chu SH, Qi J, Wang X, Delaney C, Bernt KM, Root DE, Hahn WC, Bradner JE, Armstrong SA.
Nat Med 21(4):335-43. doi: 10.1038/nm.3832. Epub 2015 Mar 30. 2015
7SIRT1, TRIM28
KAP1 Deacetylation by SIRT1 Promotes Non-Homologous End-Joining Repair.
Lin YH, Yuan J, Pei H, Liu T, Ann DK, Lou Z.
PLoS One 10(4):e0123935. doi: 10.1371/journal.pone.0123935. eCollection 2015. 2015
8RORC, SIRT1
SIRT1 deacetylates RORγt and enhances Th17 cell generation.
Lim HW, Kang SG, Ryu JK, Schilling B, Fei M, Lee IS, Kehasse A, Shirakawa K, Yokoyama M, Schnölzer M, Kasler HG, Kwon HS, Gibson BW, Sato H, Akassoglou K, Xiao C, Littman DR, Ott M, Verdin E.
J Exp Med 212(5):607-17. doi: 10.1084/jem.20132378. Epub 2015 Apr 27. Erratum in: J Exp Med. 2015 Jun 1;212(6):973. 2015
9RELB, SIRT1
Sequential actions of SIRT1-RELB-SIRT3 coordinate nuclear-mitochondrial communication during immunometabolic adaptation to acute inflammation and sepsis.
Liu TF, Vachharajani V, Millet P, Bharadwaj MS, Molina AJ, McCall CE.
J Biol Chem 290(1):396-408. doi: 10.1074/jbc.M114.566349. Epub 2014 Nov 17. 2015
10ATP6V1B2, SIRT1
SIRT1 Interacts with and Deacetylates ATP6V1B2 in Mature Adipocytes.
Kim SY, Zhang Q, Brunmeir R, Han W, Xu F.
PLoS One 10(7):e0133448. doi: 10.1371/journal.pone.0133448. eCollection 2015. 2015
11NAMPT, SIRT1
The function of nicotinamide phosphoribosyltransferase in the heart.
Hsu CP, Yamamoto T, Oka S, Sadoshima J.
DNA Repair (Amst) NA Repair (Amst). 2014 Sep 29. pii: S1568-7864(14)00221-3. doi: 10.1016/j.dnarep.2014.08.005. [Epub ahead of print] 2014
12FOXO3, SIRT1, TERT
FOXO3a potentiates hTERT gene expression by activating c-MYC and extends the replicative life-span of human fibroblast.
Yamashita S, Ogawa K, Ikei T, Fujiki T, Katakura Y.
PLoS One 9(7):e101864. doi: 10.1371/journal.pone.0101864. eCollection 2014. 2014
13CCAR2, CHEK2, SIRT1
Chk2 and REGγ-dependent DBC1 regulation in DNA damage induced apoptosis.
Magni M, Ruscica V, Buscemi G, Kim JE, Nachimuthu BT, Fontanella E, Delia D, Zannini L.
Nucleic Acids Res 42(21):13150-60. doi: 10.1093/nar/gku1065. Epub 2014 Oct 31. 2014
14PACS2, SIRT1, TP53
The multifunctional sorting protein PACS-2 regulates SIRT1-mediated deacetylation of p53 to modulate p21-dependent cell-cycle arrest.
Atkins KM, Thomas LL, Barroso-González J, Thomas L, Auclair S, Yin J, Kang H, Chung JH, Dikeakos JD, Thomas G.
Cell Rep 8(5):1545-57. doi: 10.1016/j.celrep.2014.07.049. Epub 2014 Aug 21. 2014
15CARM1, CCNA1, CCNB1, ELAVL1, FOS, SIRT1
Loss of CARM1 is linked to reduced HuR function in replicative senescence.
Pang L, Tian H, Chang N, Yi J, Xue L, Jiang B, Gorospe M, Zhang X, Wang W.
BMC Mol Biol 14:15. doi: 10.1186/1471-2199-14-15. 2013
16SIRT1, STAT5A, STAT5B
SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.
Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y.
Proc Natl Acad Sci U S A 110(37):14948-53. doi: 10.1073/pnas.1220606110. Epub 2013 Aug 26. 2013
17CCAR2, KAT8, SIRT1
hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1.
Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, Chen J.
Mol Cell Biol 33(24):4960-70. doi: 10.1128/MCB.00874-13. Epub 2013 Oct 14. 2013
18HIPK2, SIRT1
SIRT1 negatively regulates the protein stability of HIPK2.
Hwang J, Lee SY, Choi JR, Shin KS, Choi CY, Kang SJ.
Biochem Biophys Res Commun 441(4):799-804. doi: 10.1016/j.bbrc.2013.10.133. Epub 2013 Nov 5. 2013
19RRP8, SIRT1, SUV39H1
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability.
Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J.
Mol Cell Biol 33(19):3835-48. doi: 10.1128/MCB.00476-13. Epub 2013 Jul 29. 2013
20NMNAT1, RRP8, SIRT1
The NAD+ synthesis enzyme nicotinamide mononucleotide adenylyltransferase (NMNAT1) regulates ribosomal RNA transcription.
Song T, Yang L, Kabra N, Chen L, Koomen J, Haura EB, Chen J.
J Biol Chem 288(29):20908-17. doi: 10.1074/jbc.M113.470302. Epub 2013 Jun 4. 2013
21NAMPT, NR1D1, SIRT1
Involvement of the clock gene Rev-erb alpha in the regulation of glucagon secretion in pancreatic alpha-cells.
Vieira E, Marroquí L, Figueroa AL, Merino B, Fernandez-Ruiz R, Nadal A, Burris TP, Gomis R, Quesada I.
PLoS One 8(7):e69939. doi: 10.1371/journal.pone.0069939. 2013
22RETN, SIRT1
Resistin impairs SIRT1 function and induces senescence-associated phenotype in hepatocytes.
Yu A, Zheng Y, Zhang R, Huang J, Zhu Z, Zhou R, Jin D, Yang Z.
Mol Cell Endocrinol 377(1-2):23-32. doi: 10.1016/j.mce.2013.06.028. Epub 2013 Jul 1. 2013
23SIRT1, TDG
Histone deacetylase SIRT1 modulates and deacetylates DNA base excision repair enzyme thymine DNA glycosylase.
Madabushi A, Hwang BJ, Jin J, Lu AL.
Biochem J 456(1):89-98. doi: 10.1042/BJ20130670. 2013
24HNF1A, SIRT1
Hepatic deletion of SIRT1 decreases hepatocyte nuclear factor 1α/farnesoid X receptor signaling and induces formation of cholesterol gallstones in mice.
Purushotham A, Xu Q, Lu J, Foley JF, Yan X, Kim DH, Kemper JK, Li X.
Mol Cell Biol 32(7):1226-36. Epub 2012 Jan 30. 2012
25SIRT1
NAD-dependent histone deacetylase, SIRT1, plays essential roles in the maintenance of hematopoietic stem cells.
Matsui K, Ezoe S, Oritani K, Shibata M, Tokunaga M, Fujita N, Tanimura A, Sudo T, Tanaka H, McBurney MW, Matsumura I, Kanakura Y.
Biochem Biophys Res Commun 418(4):811-7. doi: 10.1016/j.bbrc.2012.01.109. Epub 2012 Jan 28. 2012
26SIRT1
A deacetylase-deficient SIRT1 variant opposes full-length SIRT1 in regulating tumor suppressor p53 and governs expression of cancer-related genes.
Shah ZH, Ahmed SU, Ford JR, Allison SJ, Knight JR, Milner J.
Mol Cell Biol 32(3):704-16. doi: 10.1128/MCB.06448-11. Epub 2011 Nov 28. 2012
27FOXO3, GADD45A, NAMPT, SIRT1
NAMPT pathway is involved in the FOXO3a-mediated regulation of GADD45A expression.
Thakur BK, Lippka Y, Dittrich T, Chandra P, Skokowa J, Welte K.
Biochem Biophys Res Commun 420(4):714-20. doi: 10.1016/j.bbrc.2012.03.017. Epub 2012 Mar 10. 2012
28SIRT1
Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes.
Busch F, Mobasheri A, Shayan P, Stahlmann R, Shakibaei M.
J Biol Chem 287(31):25770-81. doi: 10.1074/jbc.M112.355420. Epub 2012 Jun 11. 2012
29KAT5, KAT8, SIRT1
SIRT1 negatively regulates the activities, functions, and protein levels of hMOF and TIP60.
Peng L, Ling H, Yuan Z, Fang B, Bloom G, Fukasawa K, Koomen J, Chen J, Lane WS, Seto E.
Mol Cell Biol 32(14):2823-36. doi: 10.1128/MCB.00496-12. Epub 2012 May 14. 2012
30EPO, GATA4, SIRT1, TAL1
GATA-binding protein 4 (GATA-4) and T-cell acute leukemia 1 (TAL1) regulate myogenic differentiation and erythropoietin response via cross-talk with Sirtuin1 (Sirt1).
Wang L, Jia Y, Rogers H, Wu YP, Huang S, Noguchi CT.
J Biol Chem 287(36):30157-69. doi: 10.1074/jbc.M112.376640. Epub 2012 Jul 7. 2012
31SIRT1
Genetic analysis of the SIRT1 gene promoter in ventricular septal defects.
Shan J, Pang S, Wanyan H, Xie W, Qin X, Yan B.
Biochem Biophys Res Commun 425(4):741-5. doi: 10.1016/j.bbrc.2012.07.145. 2012
32SIRT1
Genetic analysis of SIRT1 gene promoter in sporadic Parkinson's disease.
Zhang A, Wang H, Qin X, Pang S, Yan B.
Biochem Biophys Res Commun 422(4):693-6. doi: 10.1016/j.bbrc.2012.05.059. Epub 2012 May 18. 2012
33CTNNB1, SIRT1, ZG16B
SIRT1 inhibits proliferation of pancreatic cancer cells expressing pancreatic adenocarcinoma up-regulated factor (PAUF), a novel oncogene, by suppression of β-catenin.
Cho IR, Koh SS, Malilas W, Srisuttee R, Moon J, Choi YW, Horio Y, Oh S, Chung YH.
Biochem Biophys Res Commun 423(2):270-5. doi: 10.1016/j.bbrc.2012.05.107. Epub 2012 May 26. 2012
34IL12A, IL12B, SIRT1
Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells.
Alvarez Y, Rodríguez M, Municio C, Hugo E, Alonso S, Ibarrola N, Fernández N, Crespo MS.
J Biol Chem 287(42):35689-701. doi: 10.1074/jbc.M112.391839. Epub 2012 Aug 14. 2012
35COL1A2, NAMPT, RFX5, SIRT1
SIRT1 deacetylates RFX5 and antagonizes repression of collagen type I (COL1A2) transcription in smooth muscle cells.
Xia J, Wu X, Yang Y, Zhao Y, Fang M, Xie W, Wang H, Xu Y.
Biochem Biophys Res Commun 428(2):264-70. doi: 10.1016/j.bbrc.2012.10.043. Epub 2012 Oct 15. 2012
36FOXO1, NDN, SIRT1, TP53
Necdin controls Foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis.
Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K.
J Neurosci 32(16):5562-72. doi: 10.1523/JNEUROSCI.0142-12.2012. 2012
37SIRT1
SIRT1 stabilizes PML promoting its sumoylation.
Campagna M, Herranz D, Garcia MA, Marcos-Villar L, González-Santamaría J, Gallego P, Gutierrez S, Collado M, Serrano M, Esteban M, Rivas C.
Cell Death Differ. 18(1):72-9. 2011
38SIRT1
Inhibition of Sirt1 promotes neural progenitors toward motoneuron differentiation from human embryonic stem cells.
Zhang Y, Wang J, Chen G, Fan D, Deng M.
Biochem Biophys Res Commun 404(2):610-4. Epub 2010 Dec 7. 2011
39FOXO1, GADD45A, SIRT1
FoxO1 and SIRT1 regulate beta-cell responses to nitric oxide.
Hughes KJ, Meares GP, Hansen PA, Corbett JA.
J Biol Chem 286(10):8338-48. Epub 2011 Jan 1. 2011
40SIRT1, SUV39H1
Stabilization of Suv39H1 by SirT1 is part of oxidative stress response and ensures genome protection.
Bosch-Presegué L, Raurell-Vila H, Marazuela-Duque A, Kane-Goldsmith N, Valle A, Oliver J, Serrano L, Vaquero A.
Mol Cell 42(2):210-23. 2011
41FOXL2, SIRT1
Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase.
Benayoun BA, Georges AB, L'Hôte D, Andersson N, Dipietromaria A, Todeschini AL, Caburet S, Bazin C, Anttonen M, Veitia RA.
Hum Mol Genet 20(9):1673-86. Epub 2011 Feb 2. 2011
42NOTCH1, SIRT1
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani V, Deflorian G, Franco CA, Krüger M, Phng LK, Bentley K, Toussaint L, Dequiedt F, Mostoslavsky R, Schmidt MH, Zimmermann B, Brandes RP, Mione M, Westphal CH, Braun T, Zeiher AM, Gerhardt H, Dimmeler S, Potente M.
Nature 473(7346):234-8. Epub 2011 Apr 17. 2011
43KDM1A, SIRT1
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development.
Mulligan P, Yang F, Di Stefano L, Ji JY, Ouyang J, Nishikawa JL, Toiber D, Kulkarni M, Wang Q, Najafi-Shoushtari SH, Mostoslavsky R, Gygi SP, Gill G, Dyson NJ, Näär AM.
Mol Cell 42(5):689-99. Epub 2011 May 19. 2011
44SIRT1
Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.
Chen J, Zhang B, Wong N, Lo AW, To KF, Chan AW, Ng MH, Ho CY, Cheng SH, Lai PB, Yu J, Ng HK, Ling MT, Huang AL, Cai XF, Ko BC.
Cancer Res 71(12):4138-49. Epub 2011 Apr 28. 2011
45PPARA, SIRT1
Sirt1 acts in association with PPARα to protect the heart from hypertrophy, metabolic dysregulation, and inflammation.
Planavila A, Iglesias R, Giralt M, Villarroya F.
Cardiovasc Res 90(2):276-84. Epub 2010 Nov 29. 2011
46MAPK8, SIRT1
Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity.
Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J.
J Biol Chem 286(25):22227-34. Epub 2011 May 3. 2011
47SIRT1
Human SIRT1 associates with mitotic chromatin and contributes to chromosomal condensation.
Fatoba ST, Okorokov AL.
Cell Cycle 10(14):2317-22. Epub 2011 Jul 15. 2011
48EP300, NPAT, SIRT1
CBP/p300 and SIRT1 are involved in transcriptional regulation of S-phase specific histone genes.
He H, Yu FX, Sun C, Luo Y.
PLoS One 6(7):e22088. doi: 10.1371/journal.pone.0022088. Epub 2011 Jul 15. 2011
49SIRT1
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+).
Gerhart-Hines Z, Dominy JE Jr, Blättler SM, Jedrychowski MP, Banks AS, Lim JH, Chim H, Gygi SP, Puigserver P.
Mol Cell 44(6):851-63. doi: 10.1016/j.molcel.2011.12.005. 2011
50DNMT1, SIRT1
SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities.
Peng L, Yuan Z, Ling H, Fukasawa K, Robertson K, Olashaw N, Koomen J, Chen J, Lane WS, Seto E.
Mol Cell Biol 31(23):4720-34. doi: 10.1128/MCB.06147-11. Epub 2011 Sep 26. 2011
51KAT8, SIRT1
Modulations of hMOF autoacetylation by SIRT1 regulate hMOF recruitment and activities on the chromatin.
Lu L, Li L, Lv X, Wu XS, Liu DP, Liang CC.
Cell Res 21(8):1182-95. doi: 10.1038/cr.2011.71. Epub 2011 Apr 19. 2011
52SIRT1, SIRT4
The expression of Sirtuins 1 and 4 in peripheral blood leukocytes from patients with type 2 diabetes.
Song R, Xu W, Chen Y, Li Z, Zeng Y, Fu Y.
Eur J Histochem 55(1):e10. doi: 10.4081/ejh.2011.e10. 2011
53DYRK1A, DYRK3, SIRT1
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1.
Guo X, Williams JG, Schug TT, Li X.
J Biol Chem 285(17):13223-32. Epub 2010 Feb 18. 2010
54APEX1, SIRT1
SIRT1 deacetylates APE1 and regulates cellular base excision repair.
Yamamori T, DeRicco J, Naqvi A, Hoffman TA, Mattagajasingh I, Kasuno K, Jung SB, Kim CS, Irani K.
Nucleic Acids Res 38(3):832-45. Epub 2009 Nov 24. 2010
55SIRT1
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
Holloway KR, Calhoun TN, Saxena M, Metoyer CF, Kandler EF, Rivera CA, Pruitt K.
Proc Natl Acad Sci U S A 107(20):9216-21. Epub 2010 May 3.PMID: 20439735 2010
56SIRT1
Sirtuin 1 regulation of developmental genes during differentiation of stem cells.
Calvanese V, Lara E, Suárez-Alvarez B, Abu Dawud R, Vázquez-Chantada M, Martínez-Chantar ML, Embade N, López-Nieva P, Horrillo A, Hmadcha A, Soria B, Piazzolla D, Herranz D, Serrano M, Mato JM, Andrews PW, López-Larrea C, Esteller M, Fraga MF.
Proc Natl Acad Sci U S A 107(31):13736-41. Epub 2010 Jul 14.PMID: 20631301 2010
57NR0B2, NR5A2, SIRT1
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation.
Chanda D, Xie YB, Choi HS.
Nucleic Acids Res 38(14):4607-19. Epub 2010 Apr 7. 2010
58SIRT1, SIRT2
SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.
Peck B, Chen CY, Ho KK, Di Fruscia P, Myatt SS, Coombes RC, Fuchter MJ, Hsiao CD, Lam EW.
Mol Cancer Ther 9(4):844-55. Epub 2010 Apr 6.PMID: 20371709 2010
59SIRT1
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.
Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Näär AM.
Genes Dev. 24(13):1403-17. 2010
60SIRT1, SREBF1
SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism.
Ponugoti B, Kim DH, Xiao Z, Smith Z, Miao J, Zang M, Wu SY, Chiang CM, Veenstra TD, Kemper JK.
J Biol Chem 285(44):33959-70. Epub 2010 Sep 3. 2010
61SIRT1, XPC
Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C.
Ming M, Shea CR, Guo X, Li X, Soltani K, Han W, He YY.
Proc Natl Acad Sci U S A 107(52):22623-8. Epub 2010 Dec 13. 2010
62SIRT1
SIRT1 contributes to telomere maintenance and augments global homologous recombination.
Palacios JA, Herranz D, De Bonis ML, Velasco S, Serrano M, Blasco MA.
J Cell Biol 191(7):1299-313. 2010
63SIRT1, XPA
SIRT1 regulates UV-induced DNA repair through deacetylating XPA.
Fan W, Luo J.
Mol Cell 39(2):247-58. doi: 10.1016/j.molcel.2010.07.006. 2010
64FOXL2, SIRT1
Positive and negative feedback regulates the transcription factor FOXL2 in response to cell stress: evidence for a regulatory imbalance induced by disease-causing mutations.
Benayoun BA, Batista F, Auer J, Dipietromaria A, L'Hôte D, De Baere E, Veitia RA.
Hum Mol Genet 18(4):632-44. Epub 2008 Nov 14. 2009
65CSNK2A1, SIRT1
Carboxy-terminal phosphorylation of SIRT1 by protein kinase CK2.
Zschoernig B, Mahlknecht U.
Biochem Biophys Res Commun 381(3):372-7. Epub 2009 Feb 21. 2009
66SIRT1
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?
Jung-Hynes B, Nihal M, Zhong W, Ahmad N.
J Biol Chem. 284(6):3823-32 2009
67SIRT1
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity.
Canto, C.; Gerhart-Hines, Z.; Feige, J. N.; Lagouge, M.; Noriega, L.; Milne, J. C.; Elliott, P. J.; Puigserver, P.; Auwerx, J.
Nature 458: 1056-1060 2009
68SIRT1
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1
Westerheide, S. D.; Anckar, J.; Stevens, S. M., Jr.; Sistonen, L.; Morimoto, R. I.
Science 323: 1063-1066 2009
69CTTN, SIRT1
Deacetylation of cortactin by SIRT1 promotes cell migration
Zhang Y, Zhang M, Dong H, Yong S, Li X, Olashaw N, Kruk PA, Cheng JQ, Bai W, Chen J, Nicosia SV, Zhang X.
Oncogene. 28(3):445-60 2009
70HSF1, SIRT1
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.
Science 323(5917):1063-6. 2009
71SIRT1
SIRT1 markedly extends replicative lifespan if the NAD+ salvage pathway is enhanced.
Ho C, van der Veer E, Akawi O, Pickering JG.
FEBS Lett 583(18):3081-5. Epub 2009 Aug 29.PMID: 19716821 2009
72PPARGC1A, SIRT1
SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma Co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD.
Amat R, Planavila A, Chen SL, Iglesias R, Giralt M, Villarroya F.
J Biol Chem 284(33):21872-80. Epub 2009 Jun 24.PMID: 19553684 2009
73NR2E1, SIRT1
Transcriptional activation of NAD+-dependent protein deacetylase SIRT1 by nuclear receptor TLX.
Iwahara N, Hisahara S, Hayashi T, Horio Y.
Biochem Biophys Res Commun 386(4):671-5. Epub 2009 Jun 23.PMID: 19555662 2009
74SIRT1, TIMP3
TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1.
Cardellini M, Menghini R, Martelli E, Casagrande V, Marino A, Rizza S, Porzio O, Mauriello A, Solini A, Ippoliti A, Lauro R, Folli F, Federici M.
Diabetes 58(10):2396-401. Epub 2009 Jul 6.PMID: 19581416 2009
75SIRT1, SIRT3
Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins.
Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y.
Proteomics 9(9):2444-56.PMID: 19343720 2009
76SIRT1
Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.
Zhang D, Li S, Cruz P, Kone BC.
J Biol Chem. 284(31):20917-26 2009
77SIRT1
Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.
Westerheide SD, Anckar J, Stevens SM Jr, Sistonen L, Morimoto RI.
Science. 323(5917):1063-6. 2009
78SIRT1
Sirt1 physically interacts with Tip60 and negatively regulates Tip60-mediated acetylation of H2AX.
Yamagata K, Kitabayashi I.
Biochem Biophys Res Commun. 390(4):1355-60. 2009
79MAPK8, SIRT1
JNK1 phosphorylates SIRT1 and promotes its enzymatic activity.
Nasrin N, Kaushik VK, Fortier E, Wall D, Pearson KJ, de Cabo R, Bordone L.
PLoS One. 4(12):e8414. 2009
80BRINP1, SIRT1
Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma.
Cha EJ, Noh SJ, Kwon KS, Kim CY, Park BH, Park HS, Lee H, Chung MJ, Kang MJ, Lee DG, Moon WS, Jang KY.
Clin Cancer Res 15(13):4453-9. Epub 2009 Jun 9. 2009
81SIRT1
Sirtuins: novel targets for metabolic disease in drug development.
Jiang WJ.
Biochem Biophys Res Commun 373(3):341-4. Epub 2008 Jun 23. Review. 2008
82CCAR2, SIRT1
DBC1 is a negative regulator of SIRT1.
Kim JE, Chen J, Lou Z.
Nature 451(7178):583-6. 2008
83SIRT1
Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression.
Hasegawa K, Wakino S, Yoshioka K, Tatematsu S, Hara Y, Minakuchi H, Washida N, Tokuyama H, Hayashi K, Itoh H.
Biochem Biophys Res Commun 372(1):51-6. Epub 2008 May 15. 2008
84SIRT1
Histone deacetylase SIRT1 modulates neuronal differentiation by its nuclear translocation.
Hisahara S, Chiba S, Matsumoto H, Tanno M, Yagi H, Shimohama S, Sato M, Horio Y.
Proc Natl Acad Sci U S A 105(40):15599-604. Epub 2008 Sep 30. 2008
85PER2, SIRT1
SIRT1 regulates circadian clock gene expression through PER2 deacetylation.
Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U.
Cell 134(2):317-28. 2008
86SIRT1
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control.
Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, Guarente LP, Sassone-Corsi P.
Cell 134(2):329-40. 2008
87SIRT1
Association of SIRT1 gene variation with visceral obesity.
Peeters AV, Beckers S, Verrijken A, Mertens I, Roevens P, Peeters PJ, Van Hul W, Van Gaal LF.
Hum Genet 124(4):431-6. Epub 2008 Sep 27. 2008
88SIRT1
SIRTUIN 1: regulating the regulator.
Zschoernig B, Mahlknecht U.
Biochem Biophys Res Commun 376(2):251-5. Epub 2008 Sep 5. Review. 2008
89SIRT1
SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging.
Oberdoerffer P, Michan S, McVay M, Mostoslavsky R, Vann J, Park SK, Hartlerode A, Stegmuller J, Hafner A, Loerch P, Wright SM, Mills KD, Bonni A, Yankner BA, Scully R, Prolla TA, Alt FW, Sinclair DA.
Cell 135(5):907-18. 2008
90SIRT1
Negative regulation of the deacetylase SIRT1 by DBC1
Zhao, W.; Kruse, J.-P.; Tang, Y.; Jung, S. Y.; Qin, J.; Gu, W.
Nature 451: 587-590 2008
91SIRT1, STK11, STRADA
SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation.
Lan F, Cacicedo JM, Ruderman N, Ido Y.
J Biol Chem 283(41):27628-35. Epub 2008 Aug 7. 2008
92SIRT1
Sirt1 protects the heart from aging and stress.
Hsu CP, Odewale I, Alcendor RR, Sadoshima J.
Biol Chem 389(3):221-31. Review.PMID: 18208353 2008
93AGTR1, SIRT1
SIRT1, a longevity gene, downregulates angiotensin II type 1 receptor expression in vascular smooth muscle cells.
Miyazaki R, Ichiki T, Hashimoto T, Inanaga K, Imayama I, Sadoshima J, Sunagawa K.
Arterioscler Thromb Vasc Biol 28(7):1263-9. Epub 2008 Apr 17.PMID: 18420994 2008
94JUN, SIRT1
Inhibition of transcriptional activity of c-JUN by SIRT1.
Gao Z, Ye J.
Biochem Biophys Res Commun. 376(4):793-6. 2008
95SIRT1
Modulation of SIRT1 expression in different neurodegenerative models and human pathologies.
Pallàs M, Pizarro JG, Gutierrez-Cuesta J, Crespo-Biel N, Alvira D, Tajes M, Yeste-Velasco M, Folch J, Canudas AM, Sureda FX, Ferrer I, Camins A.
Neuroscience 154(4):1388-97. Epub 2008 May 3. 2008
96SIRT1
Brain SIRT1: anatomical distribution and regulation by energy availability.
Ramadori G, Lee CE, Bookout AL, Lee S, Williams KW, Anderson J, Elmquist JK, Coppari R.
J Neurosci 28(40):9989-96. 2008
97SIRT1
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis.
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH.
EMBO J 26(13):3169-3179. Epub 2007 Jun 21. 2007
98SIRT1, NOS3
SIRT1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase.
Mattagajasingh I, Kim CS, Naqvi A, Yamamori T, Hoffman TA, Jung SB, Dericco J, Kasuno K, Irani K.
Proc Natl Acad Sci U S A 104(37):14855-60. Epub 2007 Sep 4. 2007
99SENP1, SIRT1
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress.
Yang Y, Fu W, Chen J, Olashaw N, Zhang X, Nicosia SV, Bhalla K, Bai W.
Nat Cell Biol 9(11):1253-1262. Epub 2007 Oct 14. 2007
100SIRT1, SUV39H1
SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation.
Vaquero A, Scher M, Erdjument-Bromage H, Tempst P, Serrano L, Reinberg D.
Nature 450(7168):440-4. 2007
101SIRT1, UCP3
SIRT1 Is Involved in Glucocorticoid-mediated Control of Uncoupling Protein-3 Gene Transcription.
Amat R, Solanes G, Giralt M, Villarroya F.
J Biol Chem 282(47):34066-76. Epub 2007 Sep 20. 2007
102SIRT1
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.
Milne JC, Lambert PD, Schenk S, Carney DP, Smith JJ, Gagne DJ, Jin L, Boss O, Perni RB, Vu CB, Bemis JE, Xie R, Disch JS, Ng PY, Nunes JJ, Lynch AV, Yang H, Galonek H, Israelian K, Choy W, Iffland A, Lavu S, Medvedik O, Sinclair DA, Olefsky JM, Jirousek MR, Elliott PJ, Westphal CH.
Nature 450(7170):712-6. 2007
103SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, SIRT8
Sirtuins: critical regulators at the crossroads between cancer and aging.
Saunders LR, Verdin E.
Oncogene 26(37):5489-504. Review. 2007
104SIRT1
Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity
Kim, E.-J.; Kho, J.-H.; Kang, M.-R.; Um, S.-J.
Mol Cell. 28: 277-290 2007
105SIRT1
Phosphorylation of HuR by Chk2 regulates SIRT1 expression
Abdelmohsen, K.; Pullmann, R., Jr.; Lal, A.; Kim, H. H.; Galban, S.; Yang, X.; Blethrow, J. D.; Walker, M.; Shubert, J.; Gillespie, D. A.; Furneaux, H.; Gorospe, M.
Mol Cell. 25: 543-557 2007
106SIRT1
SIRT1 regulates the function of the Nijmegen breakage syndrome protein
Yuan, Z.; Zhang, X.; Sengupta, N.; Lane, W. S.; Seto, E.
Mol Cell. 27: 149-162 2007
107HIC1, SIRT1
Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex.
Zhang Q, Wang SY, Fleuriel C, Leprince D, Rocheleau JV, Piston DW, Goodman RH.
Proc Natl Acad Sci U S A 104(3):829-33. Epub 2007 Jan 9. 2007
108SIRT1
SIRT1 controls endothelial angiogenic functions during vascular growth.
Potente M, Ghaeni L, Baldessari D, Mostoslavsky R, Rossig L, Dequiedt F, Haendeler J, Mione M, Dejana E, Alt FW, Zeiher AM, Dimmeler S.
Genes Dev 21(20):2644-58.PMID: 17938244 2007
109SIRT1
Sirt1 modulates premature senescence-like phenotype in human endothelial cells.
Ota H, Akishita M, Eto M, Iijima K, Kaneki M, Ouchi Y.
J Mol Cell Cardiol 43(5):571-9. Epub 2007 Aug 22.PMID: 17916362 2007
110SIRT1
Sirt1 regulates aging and resistance to oxidative stress in the heart.
Alcendor RR, Gao S, Zhai P, Zablocki D, Holle E, Yu X, Tian B, Wagner T, Vatner SF, Sadoshima J.
Circ Res 100(10):1512-21. Epub 2007 Apr 19. 2007
111SIRT1
SIRT1 deacetylates and positively regulates the nuclear receptor LXR.
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L.
Mol Cell. 28(1):91-106. 2007
112SIRT1
Cloning, chromosomal characterization and mapping of the NAD-dependent histone deacetylases gene sirtuin 1.
Voelter-Mahlknecht S, Mahlknecht U.
Int J Mol Med 17(1):59-67. 2006
113SIRT1
Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells.
Ota H, Tokunaga E, Chang K, Hikasa M, Iijima K, Eto M, Kozaki K, Akishita M, Ouchi Y, Kaneki M.
Oncogene 25(2):176-85. 2006
114SIRT1
Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells.
BŠckesjš CM, Li Y, Lindgren U, HaldosŽn LA.
J Bone Miner Res 21(7):993-1002. 2006
115SIRT1
Calorie restriction--the SIR2 connection.
Guarente L, Picard F.
Cell 120(4):473-82. 2005
116PPARGC1A, SIRT1
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Rodgers JT, Lerin C, Haas W, Gygi SP, Spiegelman BM, Puigserver P.
Nature 434(7029):113-8. 2005
117SIRT1
Increase in activity during calorie restriction requires Sirt1.
Chen D, Steele AD, Lindquist S, Guarente L.
Science 310(5754):1641. 2005
118HIC1, SIRT1
Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.
Chen WY, Wang DH, Yen RC, Luo J, Gu W, Baylin SB.
Cell 123(3):437-48. 2005
119SIRT1
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Bouras T, Fu M, Sauve AA, Wang F, Quong AA, Perkins ND, Hay RT, Gu W, Pestell RG.
J Biol Chem 280(11):10264-76. Epub 2005 Jan 4. 2005
120SIRT1
Mechanism of human SIRT1 activation by resveratrol.
Borra MT, Smith BC, Denu JM.
J Biol Chem 280(17):17187-95. Epub 2005 Mar 4. 2005
121PPARGC1A, SIRT1
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}.
Nemoto S, Fergusson MM, Finkel T.
J Biol Chem 280(16):16456-60. Epub 2005 Feb 16. 2005
122SIRT1
SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.
Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L.
J Biol Chem 280(48):40364-74. Epub 2005 Sep 23. 2005
123SIRT1
Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation
Yang Y, Hou H, Haller EM, Nicosia SV, Bai W.
EMBO J. 24(5):1021-32 2005
124SIRT1
FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.
Kitamura YI, Kitamura T, Kruse JP, Raum JC, Stein R, Gu W, Accili D.
2(3):153-63. 2(3):153-63. 2005
125FOXO3, SIRT1
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase.
Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin Y, Tran H, Ross SE, Mostoslavsky R, Cohen HY, Hu LS, Cheng HL, Jedrychowski MP, Gygi SP, Sinclair DA, Alt FW, Greenberg ME.
Science 303(5666):2011-5. Epub 2004 Feb 19. 2004
126SIRT1
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma.
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Oliveira RM, Leid M, McBurney MW, Guarente L.
Nature 429(6993):771-6. Epub 2004 Jun 02. 2004
127SIRT1
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase.
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de Cabo R, Sinclair DA.
Science 305(5682):390-2. Epub 2004 Jun 17. 2004
128SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
Araki T, Sasaki Y, Milbrandt J.
Science 305(5686):1010-3. 2004
129SIRT1, FOXO4
FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1).
van der Horst A, Tertoolen LG, de Vries-Smits LM, Frye RA, Medema RH, Burgering BM.
J Biol Chem 279(28):28873-9. Epub 2004 May 4. 2004
130SIRT1
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.
Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P, Reinberg D.
Mol Cell. 16(1):93-105 2004
131SIRT1
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase.
Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, Mayo MW.
EMBO J. 23(12):2369-80. 2004
132SIRT1
The mammalian SIR2-alpha protein has a role in embryogenesis and gametogenesis
McBurney, M. W.; Yang, X.; Jardine, K.; Hixon, M.; Boekelheide, K.; Webb, J. R.; Lansdorp, P. M.; Lemieux, M.
Mol Cell Biol. 23: 38-54 2003
133SIRT1
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.
Howitz, K. T.; Bitterman, K. J.; Cohen, H. Y.; Lamming, D. W.; Lavu, S.; Wood, J. G.; Zipkin, R. E.; Chung, P.; Kisielewski, A.; Zhang, L.-L.; Scherer, B.; Sinclair, D. A.
Nature 425(6954):191-6 2003
134SIRT2, SIRT1
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence.
Langley E, Pearson M, Faretta M, Bauer UM, Frye RA, Minucci S, Pelicci PG, Kouzarides T.
EMBO J 21(10):2383-96. 2002
135SIRT1
Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1.
Bitterman KJ, Anderson RM, Cohen HY, Latorre-Esteves M, Sinclair DA.
J Biol Chem 277(47):45099-107. Epub 2002 Sep 23. 2002
136SIRT1
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase.
Vaziri H, Dessain SK, Ng Eaton E, Imai SI, Frye RA, Pandita TK, Guarente L, Weinberg RA.
Cell 107(2):149-59. 2001
137SIRT1
Negative control of p53 by Sir2alpha promotes cell survival under stress.
Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, Guarente L, Gu W.
Cell 107(2):137-48. 2001
138SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
Frye RA.
Biochem Biophys Res Commun 273(2):793-8. 2000
139SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
Frye RA.
Biochem Biophys Res Commun 260(1):273-9. 1999