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FLASH GENE
Symbol LHX4 contributors: mct/npt - updated : 26-08-2008
HGNC name LIM homeobox 4
HGNC id 21734
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two amino terminal tandemly repeated LIM motifs
  • a C terminus helix-turn-helix (homeodomain) binding domain
    • HOMOLOGY
    interspecies ortholog to murine Lhx4
    intraspecies paralog to LHX3
    Homologene
    FAMILY
  • LIM-homeobox gene family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • LIM homeodomain transcription factor involved in pituitary ontogenesis
  • play essential roles in pituitary gland and nervous system development (Mullen 2007)
  • coordinating brain development and skull morphogenesis
  • transactivator of pituitary genes
  • playing a critical role in the development of motor neurons and in specification and expansion of specialized anterior pituitary cells
  • may be playing an important role, possibly as an activator, in leukemogenesis
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS development
    text
  • morphogenetic organizer of cephalic development
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SLB
  • LHX4 may act as a potential tumor suppressor in hepatocarcinogenesis, (LHX4 expression increased in adult liver in a manner that parallel AFP repression) suggesting that targeting LHX4 to downregulate AFP might have therapeutic implications
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PCDST , DEL1QM
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    in t(1;14) (q25;q32) with IGHG1/LHX4 fusion gene in pre-acute lymphoblastic leukemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    cooperating with Lhx3 in pituitary development and motor neuron specification in mice