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FLASH GENE

Symbol

GNG8

contributors: KTN/npt - updated : 09/09/2008

HGNC name	guanine nucleotide binding protein (G protein), gamma 8
HGNC id	19664

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	0.60 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed GNG8 2 - 213 7.7 70 - -

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

conjugated

LipoP

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to dog GNG8 (98.6 pc)
	homolog to rattus Gng8 (98.6 pc)
	homolog to murine Gng8 (98.6 pc)

Homologene

FAMILY

G protein gamma family

CATEGORY

signaling , receptor membrane G

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	lipid-anchor
	cytoplasmic side

basic FUNCTION	involved as a modulator or transducer in various transmembrane signaling systems
	required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

hormonal , signal transduction

hormone-mediated signaling

a component	prenylation
	heterotrimeric G-protein complex

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS