Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SF3B1 | contributors: mct - updated : 06-11-2015 |
HGNC name | splicing factor 3b, subunit 1, 155kDa |
HGNC id | 10768 |
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Location | 2q33.1 Physical location : 198.256.699 - 198.299.771 |
Synonym name | |
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Synonym symbol(s) | SAP155, PRP10, PRPF10, SF3b155, Hsh155, MDS |
DNA |
TYPE | functioning gene |
STRUCTURE | 43.07 kb 26 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
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MAPPING | cloned | Y | linked | N | status | confirmed |
RNA |
TRANSCRIPTS | type | messenger |
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EXPRESSION |
Type | ubiquitous |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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tissue |
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cells |
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cell lineage
cell lines
| fluid/secretion
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at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
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motifs/domains
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HOMOLOGY |
interspecies | homolog to rattus Sf3b1 (100 pc) |
homolog to murine Sf3b1 (99.9 pc) |
Homologene |
FAMILY |
CATEGORY | RNA associated , tumor suppressor |
SUBCELLULAR LOCALIZATION | intracellular |
intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles | |
text | |
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basic FUNCTION | |
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CELLULAR PROCESS | nucleotide, RNA splicing |
PHYSIOLOGICAL PROCESS | development |
text |
PATHWAY |
metabolism |
signaling |
a component | |
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INTERACTION |
DNA | binding |
RNA |
small molecule |
protein | |
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cell & other |
REGULATION |
Phosphorylated by | DYRK1A (DYRK1A ias a protein kinase that phosphorylates SF3B1) |
Other | phosphorylation on Thr-244, Thr-248 and Thr-313 by cyclin-dependent kinases, occurs concomitantly with the splicing catalytic steps |
ASSOCIATED DISORDERS |
corresponding disease(s) |
Other morbid association(s) |
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Susceptibility |
Variant & Polymorphism
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Candidate gene
Marker
| Therapy target
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ANIMAL & CELL MODELS |