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FLASH GENE
Symbol NR4A1 contributors: mct - updated : 02-05-2018
HGNC name nuclear receptor subfamily 4, group A, member 1
HGNC id 7980
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
constitutional     --over  
in a majority of human colon tumors compared to their nontumorous tissues (
tumoral     --low  
of NR4A1 and NR4A3 was a common feature in leukemic blasts from human acute myeloid leukemia patients
Susceptibility to tardive dyskinesia (TD)
Variant & Polymorphism SNP
  • single nucleotide polymorphism (SNP) marker rs2603751 and rs2701124 showed a nominal association with the risk of TD
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheroma 
    down-regulation of Nur77 by atorvastatin suggests a novel therapy strategy for atherogenesis based on suppression of vascular smooth muscle cells proliferation
    cancer  
    identification of pro-apoptotic agents inducing NR4A expression or acting as agonists suggests that these members could serve as potential targets for cancer therapy
    immunologyinflammatory 
    interesting target to treat chronic inflammatory disease
    miscelleaneoushypertension 
    Activation of Nur77 may represent a useful therapeutic strategy for preventing certain cardiovascular diseases, such as atherosclerosis and pulmonary artery hypertension
    ANIMAL & CELL MODELS
  • expression increased in diabetic mice that exhibit elevated gluconeogenesis
  • Nr4a1-deficient mice show increases in CD8 T cell effector responses with improved clearance of Listeria monocytogenes