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FLASH GENE
Symbol SIRT5 contributors: mct/npt - updated : 05-05-2009
HGNC name sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae)
HGNC id 14933
Location 6p23      Physical location : 13.574.791 - 13.614.783
Synonym name
  • SIR2-like protein 5
  • sirtuin 5
  • Synonym symbol(s) SIR2L5, FLJ36950
    EC.number 3.5.1.-
    DNA
    TYPE functioning gene
    STRUCTURE 37.65 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    GCNT2 6p24.1 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme LOC389366 6 similar to C6orf52 protein PAK1IP1 6p24.1 PAK1 interacting protein 1 C6orf53 6p24.1 chromosome 6 open reading frame 53 TMEM14B 6p25.1-p23 transmembrane protein 14B MAK 6q22 male germ cell-associated kinase GCM2 6p23 glial cells missing homolog 2 (Drosophila) LOC221711 6p24.1 hypothetical protein LOC221711 ELOVL2 6p22.3 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2 LOC389367 6 LOC389367 LOC389368 6 similar to hypothetical protein D930020E02 NEDD9 6p25-p24 neural precursor cell expressed, developmentally down-regulated 9 C6orf105 6p24.1 chromosome 6 open reading frame 105 LOC389369 6 LOC389369 HIVEP1 6p24.1 human immunodeficiency virus type I enhancer binding protein 1 EDN1 6p24.1 endothelin 1 RPEL1 6p23 RPEL repeat containing 1 TBC1D7 6p23 TBC1 domain family, member 7 GFOD1 6pter-p22.1 glucose-fructose oxidoreductase domain containing 1 C6orf114 6p23 chromosome 6 open reading frame 114 LOC391870 6 similar to ribosomal protein S4, X-linked SIRT5 6p23 sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae) RARG-1 RANBP9 6p23 RAN binding protein 9 C6orf79 6p24.3-p23 chromosome 6 open reading frame 79 MGC33993 6p23 hypothetical protein MGC33993 MRPL35P1 6q23 hypothetical protein MGC33993 CD83 6p23 CD83 antigen (activated B lymphocytes, immunoglobulin superfamily) JMJ 6p24-p23 jumonji homolog (mouse) DTNBP1 6p22.3 dystrobrevin binding protein 1 LOC346113 6p22.3 similar to ARP2/3 complex 21 kDa subunit (p21-ARC) (Actin-related protein 2/3 complex subunit 3) LOC391871 6 similar to malate dehydrogenase 1; malate dehydrogenase, soluble; Malate dehydrogenase-like enzyme MYLIP 6p23-p22.3 myosin regulatory light chain interacting protein MRPL42P2 6p22.3 myosin regulatory light chain interacting protein GMPR 6p23 guanosine monophosphate reductase SCA1 6p23 spinocerebellar ataxia 1 (olivopontocerebellar ataxia 1, autosomal dominant, ataxin 1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 splicing 3927 33.9 310 - Frye, Schlicker (2008)
  • containing a distinct 5' UTR, C-terminal coding region, and 3' UTR as compared to transcript variant 2
  • 10 splicing 2398 32.7 299 - Frye, Schlicker (2008)
  • containing a distinct 5' UTR, C-terminal coding region, and 3' UTR as compared to transcript variant 1
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Lymphoid/Immunelymph node   moderately
     thymus   predominantly
    Reproductivefemale systemuterus  highly
     male systemtestis   
     male systemprostate  highly
    Urinarybladder   highly
     kidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines retinoblastoma
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a deacetylase sirtuin-type core domain
  • HOMOLOGY
    interspecies homolog to yeast Sir2
    homolog to E.coli CobB
    ortholog to rattus Sirt5
    ortholog to murine Sirt5
    Homologene
    FAMILY
  • sirtuin family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,interspace
    intracellular,cytoplasm,organelle,mitochondria,matrix
    text can indeed be translocated into the mitochondrial intermembrane space, but also into the matrix (localization might contribute to SIRT5 regulation and substrate selection) (Schlicker 2008)
    basic FUNCTION
  • NAD(+) ADP ribosyltransferase with a protein deacetylase activity
  • can deacetylate and thereby activate a central metabolic regulator in the mitochondrial matrix, glutamate dehydrogenase (Schlicker 2008)
  • can deacetylate cytochrome c, a protein of the mitochondrial intermembrane space with a central function in oxidative metabolism, as well as apoptosis initiation (Schlicker 2008)
  • by participating in the stress response to genomic insults, sirtuins are thought to protect against cancer, but they are also emerging as direct participants in the growth of some cancers (Saunders 2007)
  • plays a pivotal role in ammonia detoxification and disposal by activating CPS1 (Nakagawa 2009)
  • CELLULAR PROCESS nucleotide, transcription, regulation
    protein, post translation
    PHYSIOLOGICAL PROCESS
    text chromatin silencing, protein ADP ribosylation
    PATHWAY
    metabolism
    signaling
    a component
  • chromatin silencing complex
  • INTERACTION
    DNA binding
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • Zn2+
  • NAD
  • protein
  • interacts with carbamoyl phosphate synthetase 1 (CPS1), an enzyme, catalyzing the initial step of the urea cycle for ammonia detoxification and disposal (Nakagawa 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS