| 1 | MAVS, SIRT5
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| SIRT5 impairs aggregation and activation of the signaling adaptor MAVS through catalyzing lysine desuccinylation.
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| Liu X, Zhu C, Zha H, Tang J, Rong F, Chen X, Fan S, Xu C, Du J, Zhu J, Wang J, Ouyang G, Yu G, Cai X, Chen Z, Xiao W.
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| EMBO J MBO J. 2020 Apr 17:e103285. doi: 10.15252/embj.2019103285. [Epub ahead of print]
2020
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| 2 | SIRT3, SIRT4, SIRT5
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| Mitochondrial Sirtuins in Skin and Skin Cancers.
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| Su S, Ndiaye M, Singh CK, Ahmad N.
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| Photochem Photobiol hotochem Photobiol. 2020 Mar 3. doi: 10.1111/php.13254. [Epub ahead of print] Review.
2020
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| 3 | SIRT3, SIRT4, SIRT5
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| Sirt4 Modulates Oxidative Metabolism and Sensitivity to Rapamycin Through Species-Dependent Phenotypes in Drosophila mtDNA Haplotypes.
|
| Sejour R, Sanguino RA, Mikolajczak M, Ahmadi W, Villa-Cuesta E.
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| G3 (Bethesda) 10(5):1599-1612. doi: 10.1534/g3.120.401174.
2020
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| 4 | SIRT5
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| Expression of SIRT5 protein in gastric cancer cells.
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| Wu ZP, Fang HX.
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| J Biol Regul Homeost Agents 33(6):1675-1683. doi: 10.23812/19-184-A.
2019
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| 5 | SIRT5
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| SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis.
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| Greene KS, Lukey MJ, Wang X, Blank B, Druso JE, Lin MJ, Stalnecker CA, Zhang C, Negrón Abril Y, Erickson JW, Wilson KF, Lin H, Weiss RS, Cerione RA.
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| Proc Natl Acad Sci U S A roc Natl Acad Sci U S A. 2019 Dec 16. pii: 201911954. doi: 10.1073/pnas.1911954116. [Epub ahead of print]
2019
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| 6 | SIRT5
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| SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue.
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| Shuai L, Zhang LN, Li BH, Tang CL, Wu LY, Li J, Li JY.
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| Diabetes 68(7):1449-1461. doi: 10.2337/db18-1103. Epub 2019 Apr 22.
2019
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| 7 | SIRT5
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| SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress.
|
| Zhang M, Wu J, Sun R, Tao X, Wang X, Kang Q, Wang H, Zhang L, Liu P, Zhang J, Xia Y, Zhao Y, Yang Y, Xiong Y, Guan KL, Zou Y, Ye D.
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| PLoS One 14(2):e0211796. doi: 10.1371/journal.pone.0211796. eCollection 2019.
2019
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| 8 | SIRT5
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| Sirtuin 5 Deficiency Does Not Compromise Innate Immune Responses to Bacterial Infections.
|
| Heinonen T, Ciarlo E, Théroude C, Pelekanou A, Herderschee J, Le Roy D, Roger T.
|
| Front Immunol 9:2675. doi: 10.3389/fimmu.2018.02675. eCollection 2018.
2018
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| 9 | SIRT5
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| Sirtuin 5 overexpression attenuates glucolipotoxicity-induced pancreatic β cells apoptosis and dysfunction.
|
| Wang Y, Liu Q, Huan Y, Li R, Li C, Sun S, Guo N, Yang M, Liu S, Shen Z.
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| Exp Cell Res 371(1):205-213. doi: 10.1016/j.yexcr.2018.08.011. Epub 2018 Aug 8.
2018
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| 10 | SIRT5
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| Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms.
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| Du Y, Hu H, Hua C, Du K, Wei T.
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| Biochem Biophys Res Commun 503(2):763-769. doi: 10.1016/j.bbrc.2018.06.073. Epub 2018 Jun 22.
2018
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| 11 | SIRT5
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| Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology.
|
| Kumar S, Lombard DB.
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| Crit Rev Biochem Mol Biol 53(3):311-334. doi: 10.1080/10409238.2018.1458071. Epub 2018 Apr 11. Review.
2018
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| 12 | SIRT5
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| SIRT5 promotes cell proliferation and invasion in hepatocellular carcinoma by targeting E2F1.
|
| Chang L, Xi L, Liu Y, Liu R, Wu Z, Jian Z.
|
| Mol Med Rep 17(1):342-349. doi: 10.3892/mmr.2017.7875. Epub 2017 Oct 25.
2018
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| 13 | SIRT5
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| Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain.
|
| Zhang Y, Bharathi SS, Rardin MJ, Lu J, Maringer KV, Sims-Lucas S, Prochownik EV, Gibson BW, Goetzman ES.
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| J Biol Chem 292(24):10239-10249. doi: 10.1074/jbc.M117.785022. Epub 2017 Apr 30.
2017
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| 14 | SIRT5
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| Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation.
|
| Guedouari H, Daigle T, Scorrano L, Hebert-Chatelain E.
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| Biochim Biophys Acta Mol Cell Res 1864(1):169-176. doi: 10.1016/j.bbamcr.2016.10.015. Epub 2016 Nov 15.
2017
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| 15 | G6PD, IDH2, SIRT5
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| SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense.
|
| Zhou L, Wang F, Sun R, Chen X, Zhang M, Xu Q, Wang Y, Wang S, Xiong Y, Guan KL, Yang P, Yu H, Ye D.
|
| EMBO Rep 17(6):811-22. doi: 10.15252/embr.201541643. Epub 2016 Apr 9.
2016
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| 16 | SIRT5, SUN2
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| SUN2 exerts tumor suppressor functions by suppressing the Warburg effect in lung cancer.
|
| Lv XB, Liu L, Cheng C, Yu B, Xiong L, Hu K, Tang J, Zeng L, Sang Y.
|
| Sci Rep 5:17940. doi: 10.1038/srep17940.
2015
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| 17 | SIRT5
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| SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target.
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| Nishida Y, Rardin MJ, Carrico C, He W, Sahu AK, Gut P, Najjar R, Fitch M, Hellerstein M, Gibson BW, Verdin E.
|
| Mol Cell 59(2):321-32. doi: 10.1016/j.molcel.2015.05.022. Epub 2015 Jun 11.
2015
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| 18 | SIRT5
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| SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.
|
| Lu W, Zuo Y, Feng Y, Zhang M.
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| Tumour Biol 35(11):10699-705. doi: 10.1007/s13277-014-2372-4. Epub 2014 Jul 29.
2014
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| 19 | SIRT5
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| SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.
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| Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
|
| Mol Cell 50(6):919-30. doi: 10.1016/j.molcel.2013.06.001.
2013
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| 20 | SIRT5
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| SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice.
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| Nakamura Y, Ogura M, Ogura K, Tanaka D, Inagaki N.
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| FEBS Lett 586(23):4076-81. doi: 10.1016/j.febslet.2012.10.009. Epub 2012 Oct 16.
2012
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| 21 | SIRT5
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| Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
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| Du J, Zhou Y, Su X, Yu JJ, Khan S, Jiang H, Kim J, Woo J, Kim JH, Choi BH, He B, Chen W, Zhang S, Cerione RA, Auwerx J, Hao Q, Lin H.
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| Science 334(6057):806-9. doi: 10.1126/science.1207861.
2011
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| 22 | CPS1, SIRT5
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| Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
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| Ogura M, Nakamura Y, Tanaka D, Zhuang X, Fujita Y, Obara A, Hamasaki A, Hosokawa M, Inagaki N.
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| Biochem Biophys Res Commun 393(1):73-8. Epub 2010 Jan 25.
2010
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| 23 | CPS1, SIRT5
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| SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.
|
| Nakagawa T, Lomb DJ, Haigis MC, Guarente L.
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| Cell 137(3):560-70. 2009
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| 24 | SIRT3, SIRT4, SIRT5
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| Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
|
| Schlicker C, Gertz M, Papatheodorou P, Kachholz B, Becker CF, Steegborn C.
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| J Mol Biol 382(3):790-801. Epub 2008 Jul 25.
2008
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| 25 | SIRT3, SIRT4, SIRT5
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| Localization of mouse mitochondrial SIRT proteins: shift of SIRT3 to nucleus by co-expression with SIRT5.
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| Nakamura Y, Ogura M, Tanaka D, Inagaki N.
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| Biochem Biophys Res Commun 366(1):174-9. Epub 2007 Dec 3.
2008
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| 26 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7, SIRT8
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| Sirtuins: critical regulators at the crossroads between cancer and aging.
|
| Saunders LR, Verdin E.
|
| Oncogene 26(37):5489-504. Review.
2007
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| 27 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration.
|
| Araki T, Sasaki Y, Milbrandt J.
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| Science 305(5686):1010-3. 2004
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| 28 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins.
|
| Frye RA.
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| Biochem Biophys Res Commun 273(2):793-8. 2000
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| 29 | SIRT1, SIRT2, SIRT3, SIRT4, SIRT5, SIRT6, SIRT7
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| Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity.
|
| Frye RA.
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| Biochem Biophys Res Commun 260(1):273-9. 1999
|