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FLASH GENE

Symbol

CORIN

contributors: mct/npt - updated : 10-01-2015

HGNC name	corin, serine protease
HGNC id	19012

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	mice deficient in either Corin or ANP displayed poor trophoblast invasion, impaired spiral artery remodeling and phenocopied human pre-eclampsia
	corin overexpression significantly prolonged life in mice with dilated cardiomyopathy
	pregnant corin- or Nppa-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia (pMID: 22437503)