| Symbol
| CORIN
| contributors: mct/npt - updated : 10-01-2015
|
| HGNC name
| corin, serine protease
|
| HGNC id
| 19012
|
| Other morbid association(s)
|
| Type | Gene Modification | Chromosome rearrangement | Protein expression | Protein Function
|
|---|
| constitutional
|
|
| --low
|
| |
in heart failure, plasma corin levels were significantly lower compared with that of healthy controls, but not in those with acute myocardial infarction (Dong 2010) | | constitutional
|
|
|
| loss of function
|
with inhibition of natriuretic peptides following exposure to IR may contribute to the development of Radiation-induced heart disease (RIHD) through the acceleration of cellular senescence  | | constitutional
|
|
| --low
|
| |
in patients with osteoporosis and the reduction was associated with high rates of bone turnover | | constitutional
|
|
| --low
|
| |
reduced corin levels in the kidney may reflect the underlying pathology in CKD (chronic kidney disease) | |
| Susceptibility
|
to heart failure to preeclampsia |
| Variant & Polymorphism
other
| corin I555(P568) allele is associated with an increased risk for death or heart failure (Rame 2009) |
|
two minor alleles (C for rs2271036 and G for rs2271037) were significantly associated to preeclampsia ( |
| 
|
| Candidate gene
| plasma corin may be used as a biomarker in the diagnosis of heart failure (Dong 2010) |
|
promising biomarker of cardiomyopathy and heart failure |
| Marker
| low serum corin levels may reflect impaired bone homeostasis in patients with osteoporosis |
Therapy target
|
| |
|
| mice deficient in either Corin or ANP displayed poor trophoblast invasion, impaired spiral artery remodeling and phenocopied human pre-eclampsia | |
corin overexpression significantly prolonged life in mice with dilated cardiomyopathy |
|
pregnant corin- or Nppa-deficient mice developed high blood pressure and proteinuria, characteristics of pre-eclampsia (pMID: 22437503) |