| basic FUNCTION
| receptor-activated non-selective calcium premeant cation channel |
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behaving in embryonic kidney as an inositol phosphate and diacylglycerol-gated channel |
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may influence sperm motility |
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mediating T-cell receptor-dependent calcium entry in human T- lymphocytes |
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required for BDNF-mediated neuronal protection and protects cerebellar granule neurons against serum deprivation-induced cell death |
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additional function of TRPC3, and TRPC7 may be to enhance secretion either by affecting transport through the Golgi stack or by increasing fusion at the plasma membrane  |
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playing an essential role for angiotensin II-induced cardiac hypertrophy |
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regulating agonist-stimulated Ca2+ mobilization by selectively mediating interaction between ORAI1 and GNB2L1 |
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necessary mediator of pathologic cardiac hypertrophy, in part through a calcineurin/NFAT signaling pathway |
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TRPC3 channels have likely important physiological functions in the fully developed cerebellum |
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is involved in adult cerebellar function |
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TRPC3-dependent currents may differ significantly in their regulation from those overexpressed in expression systems |
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a subtle activation/inhibition of voltage-independent Ca2+ channels like TRPC3 could play a crucial role in Ca2+ homeostasis and consequently in regulation of electromechanical activity of the developing heart |
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TRPC3 and TRPC6 are thus required for the normal function of cells involved in touch and hearing, and are potential components of mechanotransducing complexes |
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regulate cardiac fibroblast proliferation and differentiation, likely by controlling the Ca(2+) influx that activates extracellular signal-regulated kinase signaling |
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likely plays an important role in atrial fibrillation by promoting fibroblast pathophysiology |
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TRPC3 channels contribute to mitochondrial Ca(2+) uptake |
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role of TRPC3 and Ca(2+) influx in the regulation of BDNF secretion by human airway smooth muscle and the enhancing effects of inflammation |
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heteromeric TRPC3/TRPC1 could participate in regulating the resting cytosolic Ca(2+) levels in skeletal muscle |
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display unique gating and regulatory properties that allow for recognition and integration of multiple input stimuli including lipid mediators, cellular Ca(2+) gradients, as well as redox signals |
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obligatory requirement for a member of the TRPC family of cation channels in ER stress-induced apoptosis in macrophages, underscoring a rather selective role of the TRPC3 channel on mechanisms related to the UPR signaling in M1 macrophage |
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combines functions of an unspecific ion channel and a signal transducer |
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regulates the expression of fibronectin, a key regulatory molecule involved in the wound healing process, in response to mechanical strain via the NFKB1 pathway |
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role of TRPC3 channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells |
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is a cation channel that permeates both Ca(2+) and Na(+) |
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regulates the automaticity of embryonic stem cell-derived cardiomyocytes |
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is a major contributor to the cellular heterogeneity that introduces distinct physiological properties in Purkinje cells, conjuring functional heterogeneity in cerebellar sensorimotor integration |
