| 1 | TRPC3
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| TRPC3 deficiency attenuates high salt-induced cardiac hypertrophy by alleviating cardiac mitochondrial dysfunction.
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| Ma T, Lin S, Wang B, Wang Q, Xia W, Zhang H, Cui Y, He C, Wu H, Sun F, Zhao Z, Gao P, Zhu Z, Liu D.
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| Biochem Biophys Res Commun. Nov 19;519(4):674-681. doi: 10.1016/j.bbrc.2019.09.018. Epub 2019 Sep 19. 2019
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| 2 | TRPC3
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| TRPC3 is a major contributor to functional heterogeneity of cerebellar Purkinje cells.
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| Wu B, Blot FG, Wong AB, Osório C, Adolfs Y, Pasterkamp RJ, Hartmann J, Becker EB, Boele HJ, De Zeeuw CI, Schonewille M.
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| Elife Sep 5;8:e45590. doi: 10.7554/eLife.45590 2019
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| 3 | TRPC3
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| Mitochondrial TRPC3 promotes cell proliferation by regulating the mitochondrial calcium and metabolism in renal polycystin-2 knockdown cells.
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| Li Z, Zhou J, Li Y, Yang F, Lian X, Liu W.
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| Int Urol Nephrol. Jun;51(6):1059-1070. doi: 10.1007/s11255-019-02149-7. Epub 2019 Apr 22. 2019
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| 4 | TRPC3, TRPC6
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| Structure of the receptor-activated human TRPC6 and TRPC3 ion channels.
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| Tang Q, Guo W, Zheng L, Wu JX, Liu M, Zhou X, Zhang X, Chen L.
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| Cell Res. Jul;28(7):746-755. doi: 10.1038/s41422-018-0038-2. Epub 2018 Apr 26. 2018
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| 5 | TRPC3
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| TRPC3-mediated Ca(2+) signals as a promising strategy to boost therapeutic angiogenesis in failing hearts: The role of autologous endothelial colony forming cells.
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| Moccia F, Lucariello A, Guerra G.
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| J Cell Physiol. May;233(5):3901-3917. doi: 10.1002/jcp.26152. Epub 2017 Sep 27. 2018
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| 6 | TRPC3
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| Structure of the human lipid-gated cation channel TRPC3.
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| Fan C, Choi W, Sun W, Du J, Lü W.
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| Elife May 4;7:e36852. doi: 10.7554/eLife.36852 2018
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| 7 | SLC8A1, TRPC3
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| Coupling between the TRPC3 ion channel and the NCX1 transporter contributed to VEGF-induced ERK1/2 activation and angiogenesis in human primary endothelial cells.
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| Andrikopoulos P, Eccles SA, Yaqoob MM.
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| Cell Signal. Sep;37:12-30. doi: 10.1016/j.cellsig.2017.05.013. Epub 2017 May 20. 2017
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| 8 | TRPC3
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| TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes.
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| Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao X, Tsang SY.
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| Int J Cardiol. Jan 15;203:169-81. doi: 10.1016/j.ijcard.2015.10.018. Epub 2015 Oct 9 2016
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| 9 | TRPC3
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| Pharmacological evidence for a role of the transient receptor potential canonical 3 (TRPC3) channel in endoplasmic reticulum stress-induced apoptosis of human coronary artery endothelial cells.
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| Ampem PT, Smedlund K, Vazquez G.
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| Vascul Pharmacol ascul Pharmacol. 2015 Jul 26. pii: S1537-1891(15)00170-6. doi: 10.1016/j.vph.2015.07.011. [Epub ahead of print]
2015
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| 10 | SYPL2, TRPC3, TRPC4
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| Interaction between mitsugumin 29 and TRPC3 participates in regulating Ca(2+) transients in skeletal muscle.
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| Woo JS, Hwang JH, Huang M, Ahn MK, Cho CH, Ma J, Lee EH.
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| Biochem Biophys Res Commun 464(1):133-9. doi: 10.1016/j.bbrc.2015.06.096. Epub 2015 Jun 30.
2015
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| 11 | TRPC3
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| Modeling Suggests TRPC3 Hydrogen Bonding and Not Phosphorylation Contributes to the Ataxia Phenotype of the Moonwalker Mouse.
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| Hanson SM, Sansom MS, Becker EB.
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| Biochemistry 54(26):4033-41. doi: 10.1021/acs.biochem.5b00235. Epub 2015 Jun 26.
2015
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| 12 | TRPC3
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| Hypertrophic scar contracture is mediated by the TRPC3 mechanical force transducer via NFkB activation.
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| Ishise H, Larson B, Hirata Y, Fujiwara T, Nishimoto S, Kubo T, Matsuda K, Kanazawa S, Sotsuka Y, Fujita K, Kakibuchi M, Kawai K.
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| Sci Rep 5:11620. doi: 10.1038/srep11620.
2015
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| 13 | TRPC3
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| TRPC3-dependent synaptic transmission in central mammalian neurons.
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| Hartmann J, Konnerth A.
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| J Mol Med (Berl) Mol Med (Berl). 2015 Jun 5. [Epub ahead of print]
2015
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| 14 | TRPC3
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| The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing cerebellum.
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| Dulneva A, Lee S, Oliver PL, Di Gleria K, Kessler BM, Davies KE, Becker EB.
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| Hum Mol Genet 24(14):4114-25. doi: 10.1093/hmg/ddv150. Epub 2015 Apr 23.
2015
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| 15 | TRPC3
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| Reduced endoplasmic reticulum stress-induced apoptosis and impaired unfolded protein response in TRPC3-deficient M1 macrophages.
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| Solanki S, Dube PR, Tano JY, Birnbaumer L, Vazquez G.
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| Am J Physiol Cell Physiol 307(6):C521-31. doi: 10.1152/ajpcell.00369.2013. Epub 2014 Jul 16.
2014
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| 16 | TRPC1, TRPC3
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| Heteromeric TRPC3 with TRPC1 formed via its ankyrin repeats regulates the resting cytosolic Ca2+ levels in skeletal muscle.
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| Woo JS, Lee KJ, Huang M, Cho CH, Lee EH.
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| Biochem Biophys Res Commun 446(2):454-9. doi: 10.1016/j.bbrc.2014.02.127. Epub 2014 Mar 5.
2014
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| 17 | TRPC3
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| TRPC3: a multifunctional signaling molecule.
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| Lichtenegger M, Groschner K.
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| Handb Exp Pharmacol. 22:67-84. doi: 10.1007/978-3-642-54215-2_4. 2014
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| 18 | TRPC3, TRPM2
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| Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder.
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| Roedding AS, Tong SY, Au-Yeung W, Li PP, Warsh JJ.
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| Brain Res 1517:16-27. doi: 10.1016/j.brainres.2013.04.025. Epub 2013 Apr 18.
2013
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| 19 | TRPC3
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| TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle.
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| Vohra PK, Thompson MA, Sathish V, Kiel A, Jerde C, Pabelick CM, Singh BB, Prakash YS.
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| Biochim Biophys Acta 1833(12):2953-60. doi: 10.1016/j.bbamcr.2013.07.019. Epub 2013 Jul 27.
2013
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| 20 | TRPC3
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| Canonical transient receptor potential 3 channels regulate mitochondrial calcium uptake.
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| Feng S, Li H, Tai Y, Huang J, Su Y, Abramowitz J, Zhu MX, Birnbaumer L, Wang Y.
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| Proc Natl Acad Sci U S A 110(27):11011-6. doi: 10.1073/pnas.1309531110. Epub 2013 Jun 17.
2013
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| 21 | ADORA1, TRPC3
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| Activation of transient receptor potential canonical 3 (TRPC3)-mediated Ca2+ entry by A1 adenosine receptor in cardiomyocytes disturbs atrioventricular conduction.
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| Sabourin J, Antigny F, Robin E, Frieden M, Raddatz E.
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| J Biol Chem 287(32):26688-701. doi: 10.1074/jbc.M112.378588. Epub 2012 Jun 12.
2012
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| 22 | TRPC3
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| Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation.
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| Harada M, Luo X, Qi XY, Tadevosyan A, Maguy A, Ordog B, Ledoux J, Kato T, Naud P, Voigt N, Shi Y, Kamiya K, Murohara T, Kodama I, Tardif JC, Schotten U, Van Wagoner DR, Dobrev D, Nattel S.
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| Circulation 126(17):2051-64. doi: 10.1161/CIRCULATIONAHA.112.121830. Epub 2012 Sep 19.
2012
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| 23 | TRPC3, TRPC6
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| TRPC3 and TRPC6 are essential for normal mechanotransduction in subsets of sensory neurons and cochlear hair cells.
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| Quick K, Zhao J, Eijkelkamp N, Linley JE, Rugiero F, Cox JJ, Raouf R, Gringhuis M, Sexton JE, Abramowitz J, Taylor R, Forge A, Ashmore J, Kirkwood N, Kros CJ, Richardson GP, Freichel M, Flockerzi V, Birnbaumer L, Wood JN.
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| Open Biol 2(5):120068. doi: 10.1098/rsob.120068.
2012
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| 24 | TRPC3
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| Williams-Beuren syndrome hypercalcemia: is TRPC3 a novel mediator in calcium homeostasis?
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| Letavernier E, Rodenas A, Guerrot D, Haymann JP.
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| Pediatrics 129(6):e1626-30. doi: 10.1542/peds.2011-2507. Epub 2012 May 7.
2012
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| 25 | PRKG1, TRPC3
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| Lack of kinase regulation of canonical transient receptor potential 3 (TRPC3) channel-dependent currents in cerebellar Purkinje cells
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| Nelson C, Glitsch MD.
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| J Biol Chem. Feb 24;287(9):6326-35. doi: 10.1074/jbc.M111.246553. Epub 2011 Dec 29. 2012
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| 26 | TRPC3
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| Candidate screening of the TRPC3 gene in cerebellar ataxia.
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| Becker EB, Fogel BL, Rajakulendran S, Dulneva A, Hanna MG, Perlman SL, Geschwind DH, Davies KE.
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| Cerebellum 10(2):296-9. doi: 10.1007/s12311-011-0253-6.
2011
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| 27 | TRPC3
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| The transient receptor potential (TRP) channel TRPC3 TRP domain and AMP-activated protein kinase binding site are required for TRPC3 activation by erythropoietin.
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| Hirschler-Laszkiewicz I, Tong Q, Waybill K, Conrad K, Keefer K, Zhang W, Chen SJ, Cheung JY, Miller BA.
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| J Biol Chem 286(35):30636-46. doi: 10.1074/jbc.M111.238360. Epub 2011 Jul 14.
2011
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| 28 | ORAI1, RACK1, TRPC3
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| TRPC3 regulates agonist-stimulated Ca2+ mobilization by mediating the interaction between type I inositol 1,4,5-trisphosphate receptor, RACK1, and Orai1.
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| Woodard GE, López JJ, Jardín I, Salido GM, Rosado JA.
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| J Biol Chem 285(11):8045-53. Epub 2009 Dec 18.PMID: 20022948 2010
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| 29 | TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPC7
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| TRPC channels are necessary mediators of pathologic cardiac hypertrophy.
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| Wu X, Eder P, Chang B, Molkentin JD.
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| Proc Natl Acad Sci U S A. 107(15):7000-5. 2010
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| 30 | TRPC3, TRPC6
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| TRPC3 activation by erythropoietin is modulated by TRPC6.
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| Hirschler-Laszkiewicz I, Tong Q, Conrad K, Zhang W, Flint WW, Barber AJ, Barber DL, Cheung JY, Miller BA.
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| J Biol Chem 284(7):4567-81. Epub 2008 Dec 13.
2009
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| 31 | PKD2, TRPC3, TRPC7
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| A pathogenic C terminus-truncated polycystin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7.
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| Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, Mori Y.
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| J Biol Chem 284(49):34400-12. Epub 2009 Oct 7.PMID: 19812035 2009
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| 32 | TRPC3
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| Regulation of cardiac hypertrophy by the formation of G protein-coupled receptor--TRPC channel protein complex.
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| Nishida M, Sato Y, Nakaya M, Kurose H.
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| Nippon Yakurigaku Zasshi 134(3):131-6. Review. No abstract available.
2009
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| 33 | TRPC3
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| Enhanced expression of STIM1/Orai1 and TRPC3 in platelets from patients with type 2 diabetes mellitus.
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| Zbidi H, López JJ, Amor NB, Bartegi A, Salido GM, Rosado JA.
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| Blood Cells Mol Dis 43(2):211-3. Epub 2009 May 17.
2009
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| 34 | SCA41, TRPC3
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| A point mutation in TRPC3 causes abnormal Purkinje cell development and cerebellar ataxia in moonwalker mice.
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| Becker EB, Oliver PL, Glitsch MD, Banks GT, Achilli F, Hardy A, Nolan PM, Fisher EM, Davies KE.
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| Proc Natl Acad Sci U S A 106(16):6706-11. doi: 10.1073/pnas.0810599106. Epub 2009 Apr 7.
2009
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| 35 | TRPM4, TRPC3
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| TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel.
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| Park JY, Hwang EM, Yarishkin O, Seo JH, Kim E, Yoo J, Yi GS, Kim DG, Park N, Ha CM, La JH, Kang D, Han J, Oh U, Hong SG.
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| Biochem Biophys Res Commun 368(3):677-83. Epub 2008 Feb 8. 2008
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| 36 | EPO, TRPC3
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| TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells.
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| Tong Q, Hirschler-Laszkiewicz I, Zhang W, Conrad K, Neagley DW, Barber DL, Cheung JY, Miller BA.
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| J Biol Chem 283(16):10385-95. Epub 2008 Feb 14.
2008
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| 37 | RYR1, TRPC3
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| TRPC3-interacting triadic proteins in skeletal muscle.
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| Woo JS, Kim do H, Allen PD, Lee EH.
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| Biochem J 411(2):399-405.PMID: 18215135 2008
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| 38 | TRPC3, TRPC7
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| Increasing the expression of calcium-permeable TRPC3 and TRPC7 channels enhances constitutive secretion.
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| Lavender V, Chong S, Ralphs K, Wolstenholme AJ, Reaves BJ.
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| Biochem J 413(3):437-46.
2008
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| 39 | TRPC3,TRPC6
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| TRPC channels promote cerebellar granule neuron survival.
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| Jia Y, Zhou J, Tai Y, Wang Y.
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| Nat Neurosci 10(5):559-67. Epub 2007 Apr 1. 2007
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| 40 | TRPC3
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| Molecular cloning of TRPC3a, an N-terminally extended, store-operated variant of the human C3 transient receptor potential channel.
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| Yildirim E, Kawasaki BT, Birnbaumer L.
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| Proc Natl Acad Sci U S A 102(9):3307-11. Epub 2005 Feb 22.
2005
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| 41 | TRPC1, TRPC2, TRPC3, TRPC4, TRPC6, TRPC7
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| Transient receptor potential (TRPC) channels in human sperm: expression, cellular localization and involvement in the regulation of flagellar motility.
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| Castellano LE, Trevino CL, Rodriguez D, Serrano CJ, Pacheco J, Tsutsumi V, Felix R, Darszon A.
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| FEBS Lett 541(1-3):69-74. 2003
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| 42 | TRPC3, TRPC6
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| TRPC3 mediates T-cell receptor-dependent calcium entry in human T-lymphocytes.
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| Philipp S, Strauss B, Hirnet D, Wissenbach U, Mery L, Flockerzi V, Hoth M.
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| J Biol Chem 278(29):26629-38. Epub 2003 May 6. 2003
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| 43 | TRPC3, TRPC6
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| N-linked protein glycosylation is a major determinant for basal TRPC3 and TRPC6 channel activity.
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| Dietrich A, Mederos y Schnitzler M, Emmel J, Kalwa H, Hofmann T, Gudermann T.
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| J Biol Chem 278(48):47842-52. Epub 2003 Sep 11. 2003
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| 44 | TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPM2
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| From worm to man: three subfamilies of TRP channels.
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| Harteneck C, Plant TD, Schultz G.
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| Trends Neurosci 23(4):159-66. Review. 2000
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| 45 | TRPC3, TRPC4
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| Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3.
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| McKay RR, Szymeczek-Seay CL, Lievremont JP, Bird GS, Zitt C, Jungling E, Luckhoff A, Putney JW Jr.
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| Biochem J 351 Pt 3:735-46. 2000
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| 46 | TRPC3, TRPC6
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| Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol.
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| Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G.
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| Nature 397(6716):259-63. 1999
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| 47 | TRPC3
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| Expression of human TRPC genes in the megakaryocytic cell lines MEG01, DAMI and HEL.
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| Berg LP, Shamsher MK, El-Daher SS, Kakkar VV, Authi KS.
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| FEBS Lett 403(1):83-6. 1997
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| 48 | TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, TRPM2
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| trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.
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| Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E, Birnbaumer L.
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| Cell 85(5):661-71. 1996
|