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FLASH GENE
Symbol BCAN contributors: - updated : 30-06-2007
HGNC name brevican
HGNC id 23059
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • EGF-like domain
  • Immuloglobulin domain V type and C type
  • Sushi domain
  • C type lectin or carbohydrate domain recognition
  • HOMOLOGY
    Homologene
    FAMILY lectican family of chondroitin sulfate proteoglycan
    CATEGORY secretory , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • having sugar binding, hyaluronic acid binding activities
  • may be playing a role in both brain development and glioma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by MMP-1,-2,-3,-7,-8,-10,-13 and ADAMTS4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioma, cleavage of the Glu(395)-Ser(396) bond of brevican, is thought to be important for glioma cell invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS