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FLASH GENE
Symbol BCAN contributors: - updated : 30-06-2007
HGNC name brevican
HGNC id 23059
Location 1q31      Physical location : 156.611.739 - 156.629.318
Synonym name
  • chondroitin sulfate proteoglycan BEHAB/brevican
  • brevican proteoglycan
  • chondroitin sulfate proteoglycan 7
  • chondroitin sulfate proteoglycan BEHAB
  • brain enriched hyaluronan binding
  • Synonym symbol(s) BEHAB, CSPG7, MGC13038
    DNA
    TYPE functioning gene
    SPECIAL FEATURE arranged in tandem
    text arranged in tandem with BRAL1
    STRUCTURE 17.00 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3488 99 911 - Gary, Viapiano
    - - 2873 - 671 in extracellular matrix, highly expressed by child in cortex Gary, Viapiano
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Nervousbrainforebraincerebral cortex highly
     spinal cord    
    Reproductivefemale systemuteruscervix  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
  • EGF-like domain
  • Immuloglobulin domain V type and C type
  • Sushi domain
  • C type lectin or carbohydrate domain recognition
  • HOMOLOGY
    Homologene
    FAMILY lectican family of chondroitin sulfate proteoglycan
    CATEGORY secretory , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text extracellular matrix
    basic FUNCTION
  • having sugar binding, hyaluronic acid binding activities
  • may be playing a role in both brain development and glioma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by MMP-1,-2,-3,-7,-8,-10,-13 and ADAMTS4
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in glioma, cleavage of the Glu(395)-Ser(396) bond of brevican, is thought to be important for glioma cell invasion
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS