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FLASH GENE

Symbol

BCAN

contributors: - updated : 30-06-2007

HGNC name	brevican
HGNC id	23059

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed BEHAB FL - - 3488 99 911 - Gary, Viapiano BEHAB FS - - 2873 - 671 in extracellular matrix, highly expressed by child in cortex Gary, Viapiano

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain forebrain cerebral cortex   highly   spinal cord         Reproductive female system uterus cervix

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	EGF-like domain
	Immuloglobulin domain V type and C type
	Sushi domain
	C type lectin or carbohydrate domain recognition

HOMOLOGY

Homologene

FAMILY

lectican family of chondroitin sulfate proteoglycan

CATEGORY

secretory , structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	having sugar binding, hyaluronic acid binding activities
	may be playing a role in both brain development and glioma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

MMP-1,-2,-3,-7,-8,-10,-13 and ADAMTS4

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioma, cleavage of the Glu(395)-Ser(396) bond of brevican, is thought to be important for glioma cell invasion

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS