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FLASH GENE

Symbol

BCAN

contributors: - updated : 30-06-2007

HGNC name	brevican
HGNC id	23059

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	1q31      Physical location : 156.611.739 - 156.629.318
Synonym name	chondroitin sulfate proteoglycan BEHAB/brevican
	brevican proteoglycan
	chondroitin sulfate proteoglycan 7
	chondroitin sulfate proteoglycan BEHAB
	brain enriched hyaluronan binding
Synonym symbol(s)	BEHAB, CSPG7, MGC13038

DNA

TYPE	functioning gene
SPECIAL FEATURE	arranged in tandem
text	arranged in tandem with BRAL1
STRUCTURE	17.00 kb     14 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed BEHAB FL - - 3488 99 911 - Gary, Viapiano BEHAB FS - - 2873 - 671 in extracellular matrix, highly expressed by child in cortex Gary, Viapiano

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon     Nervous brain forebrain cerebral cortex   highly   spinal cord         Reproductive female system uterus cervix

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES		globular
STRUCTURE

motifs/domains	EGF-like domain
	Immuloglobulin domain V type and C type
	Sushi domain
	C type lectin or carbohydrate domain recognition

HOMOLOGY

Homologene

FAMILY

lectican family of chondroitin sulfate proteoglycan

CATEGORY

secretory , structural protein

SUBCELLULAR LOCALIZATION	extracellular
text	extracellular matrix

basic FUNCTION	having sugar binding, hyaluronic acid binding activities
	may be playing a role in both brain development and glioma

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

inhibited by

MMP-1,-2,-3,-7,-8,-10,-13 and ADAMTS4

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in glioma, cleavage of the Glu(395)-Ser(396) bond of brevican, is thought to be important for glioma cell invasion

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS