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FLASH GENE

Symbol

DOCK2

contributors: mct/pgu - updated : 06-09-2017

HGNC name	dedicator of cyto-kinesis 2
HGNC id	2988

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

IMD40

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed neurology neurodegenerative alzheimer DOCK2 is a COX2 expression-independent therapeutic target for neurodegenerative diseases such as AD immunology     therapeutic target for immunologic disorders caused by lymphocyte infiltration cancer hemopathy   is a potential therapeutic target for novel AML treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents

ANIMAL & CELL MODELS

T-lymphoid progenitor cells in fetal mice express two closely related CDM family molecules, Dock2 and Dock1, and and the impaired fetal thymus colonization in mice deficient for Dock2 and Dock1 was not as severe as that in mice doubly deficient for Ccr7 and Ccr9