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FLASH GENE
Symbol DOCK2 contributors: mct/pgu - updated : 06-09-2017
HGNC name dedicator of cyto-kinesis 2
HGNC id 2988
ASSOCIATED DISORDERS
corresponding disease(s) IMD40
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
Therapy target
SystemTypeDisorderPubmed
neurologyneurodegenerativealzheimer
DOCK2 is a COX2 expression-independent therapeutic target for neurodegenerative diseases such as AD
immunology  
therapeutic target for immunologic disorders caused by lymphocyte infiltration
cancerhemopathy 
is a potential therapeutic target for novel AML treatments, as this protein regulates the survival of leukemia cells with elevated FLT3 activity and sensitizes FLT3/ITD leukemic cells to conventional antileukemic agents
ANIMAL & CELL MODELS
  • T-lymphoid progenitor cells in fetal mice express two closely related CDM family molecules, Dock2 and Dock1, and and the impaired fetal thymus colonization in mice deficient for Dock2 and Dock1 was not as severe as that in mice doubly deficient for Ccr7 and Ccr9