basic FUNCTION
| being indispensable for lymphocyte chemotaxis |
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activating RAC1 in non-adherent cells |
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playing a critical role in lymphocyte migration by regulating actin cytoskeleton through Rac activation |
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playing a significant role in bone marrow lymphopoiesis, but is dispensable for hematopoietic stem/progenitor cell engraftment |
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major Rac GEF that controls motility and polarity during neutrophil chemotaxis |
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regulates microglial innate immunity independent of PTGS2 induction and DOCK2+ microglia are associated with human AD pathology |
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regulating the cell proliferation in B cell lymphoma through RAC1 and MAPK activation thus having a prominent role in hematopoietic malignancy regulates cell motility and cytokine production through the activation of RAC1 in hematopoietic cells and plays a pivotal role in the modulation of the immune system |
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role for DOCK2 in proliferation of hormone-refractory CXCR5-positive psostate carcinoma cells |
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activate the Rho-family GTPases RAC1 and CDC42 to control cell migration, morphogenesis, and phagocytosis |
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hematopoietic cell-specific, atypical guanine nucleotide exchange factor, controls lymphocyte migration through ras-related C3 botulinum toxin substrate (Rac) activation |
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mediates the GTP-GDP exchange reaction for RAC1 via its DOCK homology region (DHR)-2 |
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modulates microglia cytokine secretion, phagocytosis, and paracrine neurotoxicity |
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DOCK2 contributes to APP plaque burden via regulation of microglial innate immune function |
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DOCK5 acts with DOCK2 in neutrophils to regulate multiple cellular functions |
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DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation |
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is a novel regulator for vascular smooth muscle cell (SMC) phenotypic modulation and vascular lesion formation after vascular injury |
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is involved in cell motility, polarity, adhesion, proliferation, and apoptosis, and is essential for lymphocyte migration and activation as well as neutrophil chemotaxis |
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key molecule for lymphocyte activation and migration |