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FLASH GENE

Symbol

HTRA2

contributors: mct/npt/pgu - updated : 13-06-2019

HGNC name	HtrA serine peptidase 2
HGNC id	14348

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	neurodegeneration and juvenile lethality in mnd2 (motor neuron degeneration-2) mice result from the missense mutation ser276 to cys (S276C) in the protease domain of the nuclear-encoded mitochondrial serine protease Omi
	mice lacking Omi/HtrA2 exhibited progeria symptoms (premature aging)