| 1 | COXPD31, HTRA2, MGCA8, MIPEP, NPHPL1, PITRM1, SCAMRP, XPNPEP3
|
| Disease-Associated Genetic Variation in Human Mitochondrial Protein Import.
|
| Nicolas E, Tricarico R, Savage M, Golemis EA, Hall MJ.
|
| Am J Hum Genet 104(5):784-801. doi: 10.1016/j.ajhg.2019.03.019. Review.
2019
|
| 2 | HTRA2, RIPK1
|
| Inhibition of HtrA2 alleviated dextran sulfate sodium (DSS)-induced colitis by preventing necroptosis of intestinal epithelial cells.
|
| Zhang C, He A, Liu S, He Q, Luo Y, He Z, Chen Y, Tao A, Yan J.
|
| Cell Death Dis 10(5):344. doi: 10.1038/s41419-019-1580-7.
2019
|
| 3 | HTRA2
|
| Omi/HtrA2 Protease Associated Cell Apoptosis Participates in Blood-Brain Barrier Dysfunction.
|
| Hu Y, Bi Y, Yao D, Wang P, Li Y.
|
| Front Mol Neurosci 12:48. doi: 10.3389/fnmol.2019.00048. eCollection 2019.
2019
|
| 4 | HTRA2
|
| Progress in research on the role of Omi/HtrA2 in neurological diseases.
|
| Su XJ, Huang L, Qu Y, Mu D.
|
| Rev Neurosci 30(3):279-287. doi: 10.1515/revneuro-2018-0004.
2019
|
| 5 | HTRA2
|
| Omi/HtrA2 Participates in Age-Related Autophagic Deficiency in Rat Liver.
|
| Xu J, Jiao K, Liu X, Sun Q, Wang K, Xu H, Zhang S, Wu Y, Wu L, Liu D, Wang W, Liu H.
|
| Aging Dis 9(6):1031-1042. doi: 10.14336/AD.2018.0221. eCollection 2018 Dec.
2018
|
| 6 | HTRA2
|
| Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.
|
| Darreh-Shori T, Rezaeianyazdi S, Lana E, Mitra S, Gellerbring A, Karami A, Bogdanovic N, Lithner CU, Winblad B, Behbahani H.
|
| Mol Neurobiol ol Neurobiol. 2018 Oct 25. doi: 10.1007/s12035-018-1383-3. [Epub ahead of print]
2018
|
| 7 | HTRA1, HTRA2, HTRA3, HTRA4
|
| Structural insights into the activation mechanisms of human HtrA serine proteases.
|
| Zurawa-Janicka D, Wenta T, Jarzab M, Skorko-Glonek J, Glaza P, Gieldon A, Ciarkowski J, Lipinska B.
|
| Arch Biochem Biophys 621:6-23. doi: 10.1016/j.abb.2017.04.004. Epub 2017 Apr 7. Review.
2017
|
| 8 | HTRA2, MGCA8
|
| Pathogenic variants in HTRA2 cause an early-onset mitochondrial syndrome associated with 3-methylglutaconic aciduria.
|
| Oláhová M, Thompson K, Hardy SA, Barbosa IA, Besse A, Anagnostou ME, White K, Davey T, Simpson MA, Champion M, Enns G, Schelley S, Lightowlers RN, Chrzanowska-Lightowlers ZM, McFarland R, Deshpande C, Bonnen PE, Taylor RW.
|
| J Inherit Metab Dis 40(1):121-130. doi: 10.1007/s10545-016-9977-2. Epub 2016 Sep 30.
2017
|
| 9 | HTRA2, MGCA8
|
| Deficiency of HTRA2/Omi is associated with infantile neurodegeneration and 3-methylglutaconic aciduria.
|
| Mandel H, Saita S, Edvardson S, Jalas C, Shaag A, Goldsher D, Vlodavsky E, Langer T, Elpeleg O.
|
| J Med Genet 53(10):690-6. doi: 10.1136/jmedgenet-2016-103922. Epub 2016 May 12.
2016
|
| 10 | CSPG4, HTRA2
|
| The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2.
|
| Maus F, Sakry D, Binamé F, Karram K, Rajalingam K, Watts C, Heywood R, Krüger R, Stegmüller J, Werner HB, Nave KA, Krämer-Albers EM, Trotter J.
|
| PLoS One 10(9):e0137311. doi: 10.1371/journal.pone.0137311. eCollection 2015.
2015
|
| 11 | HTRA2, PARK13
|
| Mitochondrial serine protease HTRA2 gene mutation in Asians with coexistent essential tremor and Parkinson disease.
|
| Chao YX, Ng EY, Foo JN, Liu J, Zhao Y, Tan EK.
|
| Neurogenetics 16(3):241-2. doi: 10.1007/s10048-015-0443-3. Epub 2015 Mar 20. No abstract available.
2015
|
| 12 | HTRA2
|
| Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.
|
| Patterson VL, Zullo AJ, Koenig C, Stoessel S, Jo H, Liu X, Han J, Choi M, DeWan AT, Thomas JL, Kuan CY, Hoh J.
|
| PLoS One 9(12):e115789. doi: 10.1371/journal.pone.0115789. eCollection 2014.
2014
|
| 13 | HTRA2
|
| The protease Omi regulates mitochondrial biogenesis through the GSK3β/PGC-1α pathway.
|
| Xu R, Hu Q, Ma Q, Liu C, Wang G.
|
| Cell Death Dis 5:e1373. doi: 10.1038/cddis.2014.328.
2014
|
| 14 | HTRA2, MUL1
|
| Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.
|
| Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS.
|
| Biochim Biophys Acta 1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.
2014
|
| 15 | HTRA2, XIAP
|
| Omi/HtrA2 and XIAP are components of platelet apoptosis signalling.
|
| Winkler J, Rand ML, Schmugge M, Speer O.
|
| Thromb Haemost 109(3). [Epub ahead of print]
2013
|
| 16 | HTRA2
|
| A novel role for the mitochondrial HTRA2/OMI protease in aging.
|
| Kang S, Fernandes-Alnemri T, Alnemri ES.
|
| Autophagy 9(3):420-1. doi: 10.4161/auto.22920. Epub 2012 Dec 14.
2013
|
| 17 | HTRA2
|
| Temperature-induced changes of HtrA2(Omi) protease activity and structure.
|
| Zurawa-Janicka D, Jarzab M, Polit A, Skorko-Glonek J, Lesner A, Gitlin A, Gieldon A, Ciarkowski J, Glaza P, Lubomska A, Lipinska B.
|
| Cell Stress Chaperones 18(1):35-51. doi: 10.1007/s12192-012-0355-1. Epub 2012 Aug 1.
2013
|
| 18 | AREL1, DIABLO, HTRA2, SEPTIN4
|
| Identification of a Novel Anti-apoptotic E3 Ubiquitin Ligase That Ubiquitinates Antagonists of Inhibitor of Apoptosis Proteins SMAC, HtrA2, and ARTS.
|
| Kim JB, Kim SY, Kim BM, Lee H, Kim I, Yun J, Jo Y, Oh T, Jo Y, Chae HD, Shin DY.
|
| J Biol Chem 288(17):12014-21. doi: 10.1074/jbc.M112.436113. Epub 2013 Mar 11. 2013
|
| 19 | HTRA2, PARL
|
| The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemia.
|
| Yoshioka H, Katsu M, Sakata H, Okami N, Wakai T, Kinouchi H, Chan PH.
|
| J Cereb Blood Flow Metab 33(11):1658-65. doi: 10.1038/jcbfm.2013.139. Epub 2013 Aug 7.
2013
|
| 20 | HTRA2
|
| Effects of fluid shear stress on the expression of Omi/HtrA2 in human umbilical vein endothelial cells.
|
| Sun LL, Zhang L, Meng XL, Zhang F, Zhao Y, Jin X.
|
| Mol Med Rep ol Med Rep. 2012 Oct 22. doi: 10.3892/mmr.2012.1137. [Epub ahead of print]
2012
|
| 21 | HTRA2
|
| The protease Omi cleaves the mitogen-activated protein kinase kinase MEK1 to inhibit microglial activation.
|
| Hu Q, Li B, Xu R, Chen D, Mu C, Fei E, Wang G.
|
| Sci Signal 5(238):ra61. doi: 10.1126/scisignal.2002946.
2012
|
| 22 | HTRA2
|
| Matrix metalloproteinase-3 is activated by HtrA2/Omi in dopaminergic cells: relevance to Parkinson's disease.
|
| Shin EJ, Kim EM, Lee JA, Rhim H, Hwang O.
|
| Neurochem Int 60(3):249-56. doi: 10.1016/j.neuint.2012.01.001. Epub 2012 Jan 11.
2012
|
| 23 | HTRA2
|
| Phosphorylation of HtrA2 by cyclin-dependent kinase-5 is important for mitochondrial function.
|
| Fitzgerald JC, Camprubi MD, Dunn L, Wu HC, Ip NY, Kruger R, Martins LM, Wood NW, Plun-Favreau H.
|
| Cell Death Differ 19(2):257-66. doi: 10.1038/cdd.2011.90. Epub 2011 Jun 24.
2012
|
| 24 | HTRA2, UCHL1
|
| The serine protease HtrA2 cleaves UCH-L1 and inhibits its hydrolase activity: implication in the UCH-L1-mediated cell death.
|
| Park DW, Nam MK, Rhim H.
|
| Biochem Biophys Res Commun 415(1):24-9. doi: 10.1016/j.bbrc.2011.09.148. Epub 2011 Oct 6.
2011
|
| 25 | HTRA2
|
| Altered enzymatic activity and allele frequency of OMI/HTRA2 in Alzheimer's disease.
|
| Westerlund M, Behbahani H, Gellhaar S, Forsell C, Belin AC, Anvret A, Zettergren A, Nissbrandt H, Lind C, Sydow O, Graff C, Olson L, Ankarcrona M, Galter D.
|
| FASEB J 25(4):1345-52. doi: 10.1096/fj.10-163402. Epub 2010 Dec 16.
2011
|
| 26 | HTRA2, PSEN1
|
| Association of Omi/HtrA2 with γ-secretase in mitochondria.
|
| Behbahani H, Pavlov PF, Wiehager B, Nishimura T, Winblad B, Ankarcrona M.
|
| Neurochem Int 57(6):668-75. doi: 10.1016/j.neuint.2010.08.004. Epub 2010 Aug 10.
2010
|
| 27 | HTRA2
|
| Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.
|
| Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei E, Wang G.
|
| Cell Death Differ 17(11):1773-84. doi: 10.1038/cdd.2010.55. Epub 2010 May 14.
2010
|
| 28 | HTRA2, WT1
|
| The Wilms' tumor suppressor protein WT1 is processed by the serine protease HtrA2/Omi.
|
| Hartkamp J, Carpenter B, Roberts SG.
|
| Mol Cell 37(2):159-71. doi: 10.1016/j.molcel.2009.12.023.
2010
|
| 29 | HTRA2, ITGA7
|
| Integrin alpha 7 interacts with high temperature requirement A2 (HtrA2) to induce prostate cancer cell death.
|
| Zhu ZH, Yu YP, Zheng ZL, Song Y, Xiang GS, Nelson J, Michalopoulos G, Luo JH.
|
| Am J Pathol 177(3):1176-86. doi: 10.2353/ajpath.2010.091026. Epub 2010 Jul 22.
2010
|
| 30 | HTRA2, THAP5
|
| THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
|
| Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS.
|
| Am J Physiol Heart Circ Physiol 297(2):H643-53. Epub 2009 Jun 5.
2009
|
| 31 | HTRA2
|
| Mitochondrial serine protease HtrA2/Omi as a potential therapeutic target.
|
| Bhuiyan MS, Fukunaga K.
|
| Curr Drug Targets 10(4):372-83. Review.
2009
|
| 32 | DIABLO, HTRA2, S100A8, S100A9
|
| S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2.
|
| Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M.
|
| Biochim Biophys Acta 1783(2):297-311. Epub 2007 Nov 7. 2008
|
| 33 | HTRA2, HAX1
|
| Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons.
|
| Chao JR, Parganas E, Boyd K, Hong CY, Opferman JT, Ihle JN.
|
| Nature 452(7183):98-102. Epub 2008 Feb 20. 2008
|
| 34 | HTRA2
|
| The mitochondrial serine protease HtrA2/Omi: an overview.
|
| Vande Walle L, Lamkanfi M, Vandenabeele P.
|
| Cell Death Differ 15(3):453-60. Epub 2008 Jan 4. Review. 2008
|
| 35 | HTRA2, PARK13
|
| Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls.
|
| Simon-Sanchez J, Singleton AB.
|
| Hum Mol Genet 17(13):1988-93. Epub 2008 Mar 25. 2008
|
| 36 | HTRA2, MPV17L
|
| Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.
|
| Krick S, Shi S, Ju W, Faul C, Tsai SY, Mundel P, Böttinger EP.
|
| Proc Natl Acad Sci U S A 105(37):14106-11. Epub 2008 Sep 4.PMID: 18772386 2008
|
| 37 | HTRA1, HTRA2, HTRA3
|
| Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer.
|
| Narkiewicz J, Klasa-Mazurkiewicz D, Zurawa-Janicka D, Skorko-Glonek J, Emerich J, Lipinska B.
|
| Clin Biochem 41(7-8):561-9. doi: 10.1016/j.clinbiochem.2008.01.004. Epub 2008 Jan 16.
2008
|
| 38 | HTRA2, LATS1
|
| Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.
|
| Kuninaka S, Iida SI, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H.
|
| Oncogene 26(17):2395-406. Epub 2006 Nov 20.
2007
|
| 39 | HTRA2, PARK13
|
| Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.
|
| Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, MŸller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, KrŸger R.
|
| Hum Mol Genet 14(15):2099-111. Epub 2005 Jun 16. 2005
|
| 40 | HTRA2, PEA15
|
| Omi/HtrA2 promotes cell death by binding and degrading the anti-apoptotic protein ped/pea-15.
|
| Trencia A, Fiory F, Maitan MA, Vito P, Barbagallo AP, Perfetti A, Miele C, Ungaro P, Oriente F, Cilenti L, Zervos AS, Formisano P, Beguinot F.
|
| J Biol Chem 279(45):46566-72. Epub 2004 Aug 24. 2004
|
| 41 | HTRA2
|
| The C-terminal tail of presenilin regulates Omi/HtrA2 protease activity.
|
| Gupta S, Singh R, Datta P, Zhang Z, Orr C, Lu Z, Dubois G, Zervos AS, Meisler MH, Srinivasula SM, Fernandes-Alnemri T, Alnemri ES.
|
| J Biol Chem 279(44):45844-54. Epub 2004 Aug 4. 2004
|
| 42 | HTRA2
|
| Autocatalytic processing of HtrA2/Omi is essential for induction of caspase-dependent cell death through antagonizing XIAP.
|
| Seong YM, Choi JY, Park HJ, Kim KJ, Ahn SG, Seong GH, Kim IK, Kang S, Rhim H.
|
| J Biol Chem 279(36):37588-96. Epub 2004 Jun 16. 2004
|
| 43 | HTRA2
|
| Temperature dependent protease activity and structural properties of human HtrA2 protease.
|
| Zhang X, Chang Z.
|
| Biochemistry (Mosc) 69(6):687-92. 2004
|
| 44 | HTRA2
|
| Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.
|
| Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R.
|
| Cell Death Differ 11(2):208-16. 2004
|
| 45 | HTRA2
|
| Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis.
|
| Yang QH, Church-Hajduk R, Ren J, Newton ML, Du C.
|
| Genes Dev 17(12):1487-96. 2003
|
| 46 | HTRA2
|
| Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
|
| Li W, Srinivasula SM, Chai J, Li P, Wu JW, Zhang Z, Alnemri ES, Shi Y.
|
| Nat Struct Biol 9(6):436-41. 2002
|
| 47 | HTRA1, HTRA2, HTRA3, HTRA4
|
| The HtrA family of proteases: implications for protein composition and cell fate.
|
| Clausen T, Southan C, Ehrmann M.
|
| Mol Cell 10(3):443-55. Review. 2002
|
| 48 | HTRA2, XIAP
|
| HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
|
| Verhagen AM, Silke J, Ekert PG, Pakusch M, Kaufmann H, Connolly LM, Day CL, Tikoo A, Burke R, Wrobel C, Moritz RL, Simpson RJ, Vaux DL.
|
| J Biol Chem 277(1):445-54. Epub 2001 Oct 16. 2002
|
| 49 | LOXL3, HTRA2
|
| Central nervous system, uterus, heart, and leukocyte expression of the loxl3 gene, encoding a novel lysyl oxidase-like protein.
|
| Jourdan-Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K.
|
| Genomics 74(2):211-8. 2001
|
| 50 | HTRA2
|
| A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death.
|
| Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R.
|
| Mol Cell 8(3):613-21. 2001
|
| 51 | HTRA2, RTKN
|
| Molecular cloning, expression characterization, and mapping of a novel putative inhibitor of rho GTPase activity, RTKN, to D2S145-D2S286.
|
| Fu Q, Yu L, Liu Q, Zhang J, Zhang H, Zhao S.
|
| Genomics 66(3):328-32. 2000
|
| 52 | HTRA2
|
| Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.
|
| Faccio L, Fusco C, Chen A, Martinotti S, Bonventre JV, Zervos AS.
|
| J Biol Chem 275(4):2581-8. 2000
|
| 53 | HTRA2
|
| Characterization of human HtrA2, a novel serine protease involved in the mammalian cellular stress response.
|
| Gray CW, Ward RV, Karran E, Turconi S, Rowles A, Viglienghi D, Southan C, Barton A, Fantom KG, West A, Savopoulos J, Hassan NJ, Clinkenbeard H, Hanning C, Amegadzie B, Davis JB, Dingwall C, Livi GP, Creasy CL.
|
| Eur J Biochem 267(18):5699-710. 2000
|
| 54 | HTRA2
|
| Tissue-specific splicing of Omi stress-regulated endoprotease leads to an inactive protease with a modified PDZ motif.
|
| Faccio L, Fusco C, Viel A, Zervos AS.
|
| Genomics 68(3):343-7. 2000
|
| 55 | HTRA2
|
| Expression, purification, and functional analysis of the human serine protease HtrA2.
|
| Savopoulos JW, Carter PS, Turconi S, Pettman GR, Karran EH, Gray CW, Ward RV, Jenkins O, Creasy CL.
|
| Protein Expr Purif 19(2):227-34. 2000
|