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FLASH GENE

Symbol

P2RY2

contributors: mct/pgu - updated : 19-01-2013

HGNC name	purinergic receptor P2Y, G-protein coupled, 2
HGNC id	8541

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	18.05 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

text	three variants encoding the same protein

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_176072 3 splicing 2681 NP_788086 42 377 - 1997 9211988 NM_002564 3 splicing 2547 NP_002555 42 377 - 1997 9211988 differring in the 5' UTR compared to variant 1 NM_176071 3 splicing 2613 NP_788085 42 377 - 1997 9211988 differring in the 5' UTR compared to variant 1

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Endocrine adrenal gland           pancreas         Homo sapiens mRNA Nervous brain       moderately Homo sapiens Reproductive female system ovary       Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone       Muscular striatum skeletal

cell lineage
cell lines	osteoblastic and brain cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	targeting signal between the N terminus and 7TM
	seven transmembrane segments
	one rhodopsin-like GPCR superfamily motif

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

receptor membrane G

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,mitochondria
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endosome
	intracellular,cytoplasm,organelle,lysosome

basic FUNCTION	may be involved in cell ion homeostasis
	G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)
	playing a role as a morphogen receptor potentiating neurotrophin signaling in neuronal development and regeneration
	may participate in control of the cell cycle of endometrial carcinoma cells
	involved in signal amplification, controlling ATP gradient sensing and migration of neutrophils
	involved in nucleotide-induced primary granule release from neutrophils, requiring fibrinogen
	G-protein-coupled receptor activated by extracellular nucleotides, undergoes desensitization at many tissues, including the vascular endothelium
	mediate Ca2+ signaling in duodenocytes and contribute to duodenal mucosal bicarbonate secretion
	extracellular nucleotides, via P2RY2 and P2RY6, regulate neutrophil migration by controlling TLR2-induced IL8 release from human monocytes
	mediate metalloprotease-dependent phosphorylation of epidermal growth factor receptor and ERBB3 in salivary gland cells
	P2RY2 plays a major biological role in the corneal injury response and repair mechanisms
	major purinergic receptor in human vascular endothelial cells that mediates the cellular actions of ATP linked to vasorelaxation
	important roles of P2RY2 and ADRBK1 in chondrocyte mechanotransduction
	mediates tissue factor expression in human coronary artery endothelial cells
	P2RY2, and P2RY1 operate in tandem in inner medullary collecting duct cells to provide an adaptive mechanism for enhancing urinary NaCl excretion in the setting of high-dietary NaCl intake

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	P2RY2/FLNA interaction selectively regulates spreading and migration of vascular smooth muscle cells
	plasma membrane distribution of P2RY2 is transregulated by EGFR, revealing an unsuspected functional interplay that controls both the membrane distribution and the vasomotor activity of the P2RY2 in intact human blood vessels
	interacting with OTOP1
	CEBPB is a novel regulator of P2RY2 expression

cell & other

REGULATION

Other

predominantly responding to UTP

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --low   loss of P2RY2 immunoreactivity is associated with Alzheimer disease neuropathology

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS