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FLASH GENE
Symbol AGXT2 contributors: SGE/npt - updated : 01-09-2008
HGNC name alanine-glyoxylate aminotransferase 2
HGNC id 14412
Location 5p13.2      Physical location : 34.998.205 - 35.048.240
Synonym name
  • beta-ALAAT II
  • (R)-3-amino-2-methylpropionate--pyruvate transaminase
  • beta-alanine-pyruvate aminotransferase
  • alanine--glyoxylate aminotransferase 2, mitochondrial
  • Synonym symbol(s) AGT2, D-AIBA
    EC.number 2.6.1.44, 2.6.1.40
    DNA
    TYPE functioning gene
    STRUCTURE 49.88 kb     14 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2242 57 514 - Baker (2004)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • aminotransferase class 3 pyridoxal phosphate domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • class-III pyridoxal-phosphate-dependent aminotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • having alanine-glyoxylate transaminase activity (catalyzing the conversion of glyoxylate to glycine using L-alanine as the amino donor)
  • is able to metabolize asymmetric dimethylarginine (ADMA) resulting in decreased ADMA levels and protects from inhibition of nitric oxide production (Rodionov 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion
    text glyoxylate detoxication
    PATHWAY
    metabolism other
    signaling
    glyoxylate cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS