Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol AGXT2 contributors: SGE/npt - updated : 01-09-2008
HGNC name alanine-glyoxylate aminotransferase 2
HGNC id 14412
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 2242 57 514 - Baker (2004)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • aminotransferase class 3 pyridoxal phosphate domain
  • mono polymer homomer , tetramer
    HOMOLOGY
    Homologene
    FAMILY
  • class-III pyridoxal-phosphate-dependent aminotransferase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • having alanine-glyoxylate transaminase activity (catalyzing the conversion of glyoxylate to glycine using L-alanine as the amino donor)
  • is able to metabolize asymmetric dimethylarginine (ADMA) resulting in decreased ADMA levels and protects from inhibition of nitric oxide production (Rodionov 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS excretion
    text glyoxylate detoxication
    PATHWAY
    metabolism other
    signaling
    glyoxylate cycle
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS