| basic FUNCTION
| linking the cytoskeleton to interstitial matrix |
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required to inhibit thrombosis after deep vascular injury, contributing to endothelial cell mediated inhibition of intimal hyperplasia |
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chains presumably participate in the selective permeability of basement membranes and, additionally, the core protein may be involved in a number of biological functions such as cell binding, LDL-metabolism, basement membrane assembly, calcium binding, and growth- and neurite-promoting activities (Kallunki 1992) |
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maintaining cartilage integrity and also regulating muscle excitability |
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playing an important role in chondrogenesis and skeletal development, as well as harboring pro- and anti-angiogenic activities |
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may be involved in cartilage collagen matrix assembly, and in extracellular matrix assembly |
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negatively regulates angiogenesis counter to its proangiogenic parental molecule  |
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requires both the ITGA2 integrin and KDR for its angiostatic activity |
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novel antiangiogenic modality that could supplement established therapies in clinical use or in preclinical stages |
