| 1 | HSPG2, KDR
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| Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
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| Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV.
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| J Biol Chem 286(29):25947-62. Epub 2011 May 19.
2011
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| 2 | HSPG2
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| A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation.
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| Farach-Carson MC, Brown AJ, Lynam M, Safran JB, Carson DD.
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| Matrix Biol 27(2):150-60. Epub 2007 Oct 10.
2008
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| 3 | HSPG2
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| Reduced perlecan in mice results in chondrodysplasia resembling Schwartz-Jampel syndrome.
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| Rodgers KD, Sasaki T, Aszodi A, Jacenko O.
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| Hum Mol Genet 16(5):515-28. Epub 2007 Jan 9.
2007
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| 4 | HSPG2, SJS1
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| Spectrum of HSPG2 (Perlecan) mutations in patients with Schwartz-Jampel syndrome.
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| Stum M, Davoine CS, Vicart S, Guillot-Noel L, Topaloglu H, Carod-Artal FJ, Kayserili H, Hentati F, Merlini L, Urtizberea JA, Hammouda el-H, Quan PC, Fontaine B, Nicole S.
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| Hum Mutat 27(11):1082-91. 2006
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| 5 | HSPG2
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| Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias.
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| Kvist AJ, Johnson AE, Mörgelin M, Gustafsson E, Bengtsson E, Lindblom K, Aszódi A, Fässler R, Sasaki T, Timpl R, Aspberg A.
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| J Biol Chem 281(44):33127-39. Epub 2006 Sep 5.
2006
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| 6 | HSPG2
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| The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages.
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| Melrose J, Roughley P, Knox S, Smith S, Lord M, Whitelock J.
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| J Biol Chem 281(48):36905-14. Epub 2006 Sep 19.
2006
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| 7 | ECM1, HSPG2
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| Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.
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| Mongiat M, Fu J, Oldershaw R, Greenhalgh R, Gown AM, Iozzo RV.
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| J Biol Chem 278(19):17491-9. Epub 2003 Feb 25. 2003
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| 8 | DDSH, HSPG2, SJS1
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| Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia.
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| Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA, Govindraj P, Hassell JR, Devaney JM, Spranger J, Stevenson RE, Iannaccone S, Dalakas MC, Yamada Y.
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| Am J Hum Genet 70(5):1368-75. 2002
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| 9 | DDSH, HSPG2, SJS1
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| Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.
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| Arikawa-Hirasawa E, Wilcox WR, Le AH, Silverman N, Govindraj P, Hassell JR, Yamada Y.
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| Nat Genet 27(4):431-4. 2001
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| 10 | HSPG2, NID1, NID2
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| Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.
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| Hopf M, Gohring W, Mann K, Timpl R.
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| J Mol Biol 311(3):529-41. 2001
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| 11 | FGF7, HSPG2
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| A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor.
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| Ghiselli G, Eichstetter I, Iozzo RV.
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| Biochem J 359(Pt 1):153-63. 2001
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| 12 | HSPG2
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| Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia.
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| Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER.
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| Proc Natl Acad Sci U S A 97(12):6722-7. 2000
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| 13 | DDSH, HSPG2, SJS1
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| Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).
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| Nicole S, Davoine CS, Topaloglu H, Cattolico L, Barral D, Beighton P, Hamida CB, Hammouda H, Cruaud C, White PS, Samson D, Urtizberea JA, Lehmann-Horn F, Weissenbach J, Hentati F, Fontaine B.
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| Nat Genet 26(4):480-3. 2000
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| 14 | HSPG2
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| Structural and functional characterization of the human perlecan gene promoter.
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| Iozzo RV, et al.
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| J Biol Chem 272 : 5219-5228. 1997
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| 15 | ADCY6, AP5Z1, APAF1, ATG2A, ATMIN, BSN, CACNA1G, CCNA1, CCP110, CCP110, CHD5, DENND4B, FEM1B, FLRT2, GPRASP1, HISPPD1, HSPA12A, HSPG2, KIAA0408, LKAP, LRRTM2, MBNL1, MTSS1, NEDD4, NUP58, PJA2, PREPL, RNMT, RRP8, SEC14L5, SGSM2, SH3PXD2A, SMG1, SRGAP2, TOGARAM1, TTI1, ZBTB24, ZHX3, ZMYM4, ZNF264, ZSCAN12, ZZEF1
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| Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
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| Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
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| DNA Res 4(5):307-13. 1997
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| 16 | HSPG2
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| Structural characterization of the complete human perlecan gene and its promoter.
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| Cohen IR, et al.
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| Proc Natl Acad Sci U S A 90 : 10404-10408. 1993
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| 17 | HSPG2
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| Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
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| Kallunki P, Tryggvason K.
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| J Cell Biol 116(2):559-71.
1992
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| 18 | HSPG2
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| Heparan sulfate proteoglycan of human colon : partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1.
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| Dodge GR, et al.
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| Genomics 10 : 673-680. 1991
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| 19 | HSPG2
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| Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-p35 and identification of a BamHI restriction fragment length polymorphism.
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| Kallunki P, et al.
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| Genomics 11 : 389-396. 1991
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| 20 | HSPG2
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| In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG).
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| Wintle RF, et al.
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| Cytogenet Cell Genet 54 : 60-61. 1990
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