Citations for
1HSPG2, KDR
Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism.
Goyal A, Pal N, Concannon M, Paul M, Doran M, Poluzzi C, Sekiguchi K, Whitelock JM, Neill T, Iozzo RV.
J Biol Chem 286(29):25947-62. Epub 2011 May 19. 2011
2HSPG2
A novel peptide sequence in perlecan domain IV supports cell adhesion, spreading and FAK activation.
Farach-Carson MC, Brown AJ, Lynam M, Safran JB, Carson DD.
Matrix Biol 27(2):150-60. Epub 2007 Oct 10. 2008
3HSPG2
Reduced perlecan in mice results in chondrodysplasia resembling Schwartz-Jampel syndrome.
Rodgers KD, Sasaki T, Aszodi A, Jacenko O.
Hum Mol Genet 16(5):515-28. Epub 2007 Jan 9. 2007
4HSPG2, SJS1
Spectrum of HSPG2 (Perlecan) mutations in patients with Schwartz-Jampel syndrome.
Stum M, Davoine CS, Vicart S, Guillot-Noel L, Topaloglu H, Carod-Artal FJ, Kayserili H, Hentati F, Merlini L, Urtizberea JA, Hammouda el-H, Quan PC, Fontaine B, Nicole S.
Hum Mutat 27(11):1082-91. 2006
5HSPG2
Chondroitin sulfate perlecan enhances collagen fibril formation. Implications for perlecan chondrodysplasias.
Kvist AJ, Johnson AE, Mörgelin M, Gustafsson E, Bengtsson E, Lindblom K, Aszódi A, Fässler R, Sasaki T, Timpl R, Aspberg A.
J Biol Chem 281(44):33127-39. Epub 2006 Sep 5. 2006
6HSPG2
The structure, location, and function of perlecan, a prominent pericellular proteoglycan of fetal, postnatal, and mature hyaline cartilages.
Melrose J, Roughley P, Knox S, Smith S, Lord M, Whitelock J.
J Biol Chem 281(48):36905-14. Epub 2006 Sep 19. 2006
7ECM1, HSPG2
Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis.
Mongiat M, Fu J, Oldershaw R, Greenhalgh R, Gown AM, Iozzo RV.
J Biol Chem 278(19):17491-9. Epub 2003 Feb 25. 2003
8DDSH, HSPG2, SJS1
Structural and functional mutations of the perlecan gene cause Schwartz-Jampel syndrome, with myotonic myopathy and chondrodysplasia.
Arikawa-Hirasawa E, Le AH, Nishino I, Nonaka I, Ho NC, Francomano CA, Govindraj P, Hassell JR, Devaney JM, Spranger J, Stevenson RE, Iannaccone S, Dalakas MC, Yamada Y.
Am J Hum Genet 70(5):1368-75. 2002
9DDSH, HSPG2, SJS1
Dyssegmental dysplasia, Silverman-Handmaker type, is caused by functional null mutations of the perlecan gene.
Arikawa-Hirasawa E, Wilcox WR, Le AH, Silverman N, Govindraj P, Hassell JR, Yamada Y.
Nat Genet 27(4):431-4. 2001
10HSPG2, NID1, NID2
Mapping of binding sites for nidogens, fibulin-2, fibronectin and heparin to different IG modules of perlecan.
Hopf M, Gohring W, Mann K, Timpl R.
J Mol Biol 311(3):529-41. 2001
11FGF7, HSPG2
A role for the perlecan protein core in the activation of the keratinocyte growth factor receptor.
Ghiselli G, Eichstetter I, Iozzo RV.
Biochem J 359(Pt 1):153-63. 2001
12HSPG2
Perlecan is required to inhibit thrombosis after deep vascular injury and contributes to endothelial cell-mediated inhibition of intimal hyperplasia.
Nugent MA, Nugent HM, Iozzo RV, Sanchack K, Edelman ER.
Proc Natl Acad Sci U S A 97(12):6722-7. 2000
13DDSH, HSPG2, SJS1
Perlecan, the major proteoglycan of basement membranes, is altered in patients with Schwartz-Jampel syndrome (chondrodystrophic myotonia).
Nicole S, Davoine CS, Topaloglu H, Cattolico L, Barral D, Beighton P, Hamida CB, Hammouda H, Cruaud C, White PS, Samson D, Urtizberea JA, Lehmann-Horn F, Weissenbach J, Hentati F, Fontaine B.
Nat Genet 26(4):480-3. 2000
14HSPG2
Structural and functional characterization of the human perlecan gene promoter.
Iozzo RV, et al.
J Biol Chem 272 : 5219-5228. 1997
15ADCY6, AP5Z1, APAF1, ATG2A, ATMIN, BSN, CACNA1G, CCNA1, CCP110, CCP110, CHD5, DENND4B, FEM1B, FLRT2, GPRASP1, HISPPD1, HSPA12A, HSPG2, KIAA0408, KIAA0423, LKAP, LRRTM2, MBNL1, MTSS1, NEDD4, NUP58, PJA2, PREPL, RNMT, RRP8, SEC14L5, SGSM2, SH3PXD2A, SMG1, SRGAP2, TTI1, ZBTB24, ZHX3, ZMYM4, ZNF264, ZSCAN12, ZZEF1
Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A,Kotani H, Nomura N, Ohara O.
DNA Res 4(5):307-13. 1997
16HSPG2
Structural characterization of the complete human perlecan gene and its promoter.
Cohen IR, et al.
Proc Natl Acad Sci U S A 90 : 10404-10408. 1993
17HSPG2
Human basement membrane heparan sulfate proteoglycan core protein: a 467-kD protein containing multiple domains resembling elements of the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
Kallunki P, Tryggvason K.
J Cell Biol 116(2):559-71. 1992
18HSPG2
Heparan sulfate proteoglycan of human colon : partial molecular cloning, cellular expression, and mapping of the gene (HSPG2) to the short arm of human chromosome 1.
Dodge GR, et al.
Genomics 10 : 673-680. 1991
19HSPG2
Cloning of human heparan sulfate proteoglycan core protein, assignment of the gene (HSPG2) to 1p36.1-p35 and identification of a BamHI restriction fragment length polymorphism.
Kallunki P, et al.
Genomics 11 : 389-396. 1991
20HSPG2
In situ hybridization to human chromosome 1 of a cDNA probe for the gene encoding the basement membrane heparan sulfate proteoglycan (HSPG).
Wintle RF, et al.
Cytogenet Cell Genet 54 : 60-61. 1990