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FLASH GENE

Symbol

ZRSR2

contributors: mct - updated : 05-11-2012

HGNC name	zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
HGNC id	23019

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	Xp22.2      Physical location : 15.808.573 - 15.841.380
Synonym name	U2AF35-related protein
	U2 small nuclear ribonucleoprotein auxiliary factor,small subunit 2
	U2(RNU2) small nuclear RNA auxiliary factor 1-like 2
	CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2
	renal carcinoma antigen NY-REN-20
Synonym symbol(s)	U2AF1PL1, U2AF1RS2, U2AF1-RS2, U2AF1L2, URP, MGC142014, MGC142040, U2

DNA

TYPE	functioning gene
STRUCTURE	32.81 kb     11 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005089 11 - 1512 NP_005080 58 482 - 1999 10330123

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	arginine-serine rich domain
	a RNA-recognition motif
	two C3H1-type zinc fingers

mono polymer

heteromer , dimer

HOMOLOGY

interspecies

homolog to murine U2af1rs2

intraspecies

homolog to U2AF1L1

Homologene

FAMILY

zinc finger protein family

CATEGORY

RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION

splicing factor activity

CELLULAR PROCESS

nucleotide, RNA splicing

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

of the spliceosome

INTERACTION

DNA

RNA

binding

small molecule

protein	specifically interacting with the large subunit of the U2AF heterodimer
	physically interacts with U2AF2, as well as SRSF1 and SRSF2, with a distinct function from its homologue, U2AF1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral germinal mutation       in myelodysplasia

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS