basic FUNCTION
| catalyzing an essential step in NAD (NADP) biosynthetic pathway |
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brain-specific NMNAT2 delays injury-induced axon degeneration dependent on its NAD synthesis activity  |
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endogenous NMNAT2 prevents spontaneous degeneration of healthy axons  |
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NMNAT1, NMNAT2, NMNAT3 catalyzes the formation of nicotinamide adenine dinucleotide  |
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is a neuronal protein peripherally attached to membranes via palmitoylation, suggesting that NMNAT2 is transported to synaptic terminals via an endosomal pathway  |
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NMNAT2 activity supports axon survival through a site of action distinct from NMNAT2 transport vesicles and protein stability, a key determinant of axon protection, is enhanced by mutations that disrupt palmitoylation and dissociate NMNAT2 from these vesicles  |
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is a critical survival factor for axons  |
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NMNAT2 localisation and turnover are a valuable target for modulating axon degeneration  |
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requirement for NMNAT2 in axon maintenance even during development  |
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important functional role of NMNAT2 in TP53-mediated signaling  |
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is a critical survival factor for axons and its constant supply from neuronal cell bodies into axons is required for axon extension  |
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having a chaperone function, independent from its enzymatic activity  |
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exerts its chaperone or enzymatic function in a context-dependent manner to maintain neuronal health  |
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acts not only as a NAD synthase involved in axonal maintenance but as a molecular chaperone helping neurons to overcome protein unfolding and protein aggregation  |