Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

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FLASH GENE

Symbol

ZEB2

contributors: mct/ - updated : 04-07-2023

HGNC name	zinc finger E-box binding homeobox 2
HGNC id	14881

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

MOWS

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral         promotic invasion in eptihelial tumors tumoral     --over   in bladder tumors and is an independent predictor of poor cancer-specific survival constitutional     --over   in the epidermis of pemphigus vulgaris tumoral     --low   of GADD45G-ZEB2 axis may contribute to cellular senescence evasion and hepatocellular carcinoma (HCC) development

Susceptibility

Variant & Polymorphism

Candidate gene	biomarker of biological aggressiveness and micrometastases
Marker
Therapy target
	System Type Disorder Pubmed cancer angiogenesis

ANIMAL & CELL MODELS

	Zeb2 null mutation in mice results in early embryonic death with marked neural tube/crest defect
	mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin membranes