Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SACM1L contributors: mct - updated : 01-06-2011
HGNC name SAC1 suppressor of actin mutations 1-like (yeast)
HGNC id 17059
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
text
  • integral membrane protein of the endoplasmic reticulum and the Golgi complex
    • basic FUNCTION
  • possibility that the enzymatic function of SACM1L provides a switch for accessibility of the COPI interaction motif
  • direct roles for MAPK14 and SACM1L in transmitting growth signals to the secretory machinery
  • in quiescent cells stimulated by mitogens, rapidly shuttles back to the endoplasmic reticulum (ER), thus releasing the brake on Golgi secretion
  • executes an essential household function in mammals that involves organization of both Golgi membranes and mitotic spindles and both enzymatic activity and endoplasmic reticulum localization are important SACM1L functional properties
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • members of the coatomer I (COPI) complex as interaction partners of SACM1L
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS